The Prowess of Andrographolide as a Natural Weapon in the War against Cancer

被引：37

作者：

Farooqi, Ammad Ahmad ^{[1
]}

Attar, Rukset ^{[2
]}

Sabitaliyevich, Uteuliyev Yerzhan ^{[3
]}

Alaaeddine, Nada ^{[4
]}

de Sousa, Damiao Pergentino ^{[5
]}

Xu, Baojun ^{[6
]}

Cho, William C. ^{[7
]}

机构：

[1] Inst Biomed & Genet Engn IBGE, Dept Mol Oncol, Islamabad 44000, Pakistan

[2] Yeditepe Univ, Dept Obstet & Gynecol, TR-34755 Istanbul, Turkey

[3] Kazakhstan Med Univ KSPH, Alma Ata 050004, Kazakhstan

[4] Lebanese Univ, Fac Med Sci, Neurosci Res Ctr, Beirut 00961, Lebanon

[5] Univ Fed Paraiba, Dept Pharmaceut Sci, BR-58051970 Joao Pessoa, Paraiba, Brazil

[6] BNU HKBU United Int Coll, Food Sci & Technol Program, Zhuhai 519087, Peoples R China

[7] Queen Elizabeth Hosp, Dept Clin Oncol, Hong Kong, Peoples R China

来源：

CANCERS | 2020年 / 12卷 / 08期

关键词：

andrographolide; oncogenic signaling pathways; TRAIL; anti-cancer drug; INHIBITS TUMOR ANGIOGENESIS; TRAIL-INDUCED APOPTOSIS; CELLS; PATHWAY; DEATH; PROLIFERATION; DITERPENOIDS; METASTASIS; MECHANISMS; PANICULATA;

D O I：

10.3390/cancers12082159

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

There has been a paradigm shift in our understanding about the multifaceted nature of cancer, and a wealth of information has revealed that single-target drugs are not good enough to provide satisfactory clinical outcomes and therapeutic effects for complex diseases which involve multiple factors. Therefore, there has been a reignition to search for natural products having premium pharmacological activities aim to efficiently target multiple deregulated cellular signaling pathways. Andrographolide, a diterpene lactone fromAndrographis paniculatawas brought into to the limelight because of its ability to inhibit cancer cell proliferation and induce apoptosis. Here we reviewed andrographolide on cellular pathways regulation including Wnt/beta-catenin, mTOR, VEGF-mediated intracellular signaling, as well as TRAIL-mediated apoptosis to inhibit cancer development.

引用

页码：1 / 15

页数：15

共 68 条

[1] WNT signalling pathways as therapeutic targets in cancer [J].

Anastas, Jamie N. ;

Moon, Randall T. .

NATURE REVIEWS CANCER, 2013, 13 (01) :11-26

[2] Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer [J].

Bailey, J. M. ;

Mohr, A. M. ;

Hollingsworth, M. A. .

ONCOGENE, 2009, 28 (40) :3513-3525

[3] Increased reactive oxygen species levels cause ER stress and cytotoxicity in andrographolide treated colon cancer cells [J].

Banerjee, Aditi ;

Banerjee, Vivekjyoti ;

Czinn, Steven ;

Blanchard, Thomas .

ONCOTARGET, 2017, 8 (16) :26142-26153

[4] Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer [J].

Bao, Guo-Qing ;

Shen, Bai-Yong ;

Pan, Chun-Peng ;

Zhang, Ya-Jing ;

Shi, Min-Min ;

Peng, Cheng-Hong .

TOXICOLOGY LETTERS, 2013, 222 (01) :23-35

[5] Mining the Wnt pathway for cancer therapeutics [J].

Barker, Nick ;

Clevers, Hans .

NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (12) :997-1014

[6]

Chun Jae Yeon, 2010, Genes Cancer, V1, P868, DOI 10.1177/1947601910383416

[7]

Da Silveira e Sa R.C., 2015, NAT PROD COMMUN, V10, DOI [DOI 10.1177/1934578X1501001033, 10.1177/1934578X1501001033]

[8] A Review on Anti-Inflammatory Activity of Monoterpenes [J].

da Silveira e Sa, Rita de Cassia ;

Andrade, Luciana Nalone ;

de Sousa, Damiao Pergentino .

MOLECULES, 2013, 18 (01) :1227-1254

[9] Andrographolide Inhibits Angiogenesis by Inhibiting the Mir-21-5p/TIMP3 Signaling Pathway [J].

Dai, Jianwei ;

Lin, Yuyin ;

Duan, Youfa ;

Li, Zixuan ;

Zhou, Dalei ;

Chen, Wensheng ;

Wang, Lijing ;

Zhang, Qian-Qian .

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2017, 13 (05) :660-668

[10] mToR signaling and drug development in cancer [J].

Dancey, Janet .

NATURE REVIEWS CLINICAL ONCOLOGY, 2010, 7 (04) :209-219

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