The Multifaceted Functions of Neutrophils

被引:968
作者
Mayadas, Tanya N. [1 ,2 ]
Cullere, Xavier [1 ,2 ]
Lowell, Clifford A. [3 ]
机构
[1] Brigham & Womens Hosp, Dept Pathol, Ctr Excellence Vasc Biol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Boston, MA 02115 USA
[3] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA
来源
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 9 | 2014年 / 9卷
关键词
recruitment; receptors; cytotoxic functions; adaptive immunity; disorders; chronic diseases; SEVERE CONGENITAL NEUTROPENIA; HUMAN POLYMORPHONUCLEAR LEUKOCYTES; RECEPTOR-MEDIATED PHAGOCYTOSIS; TUMOR-ASSOCIATED NEUTROPHILS; HEPARIN-BINDING PROTEIN; NITRIC-OXIDE SYNTHASE; TOLL-LIKE RECEPTORS; NOD-LIKE RECEPTORS; FC-GAMMA-RIIB; EXTRACELLULAR TRAPS;
D O I
10.1146/annurev-pathol-020712-164023
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Neutrophils and neutrophil-like cells are the major pathogen-fighting immune cells in organisms ranging from slime molds to mammals. Central to their function is their ability to be recruited to sites of infection, to recognize and phagocytose microbes, and then to kill pathogens through a combination of cytotoxic mechanisms. These include the production of reactive oxygen species, the release of antimicrobial peptides, and the recently discovered expulsion of their nuclear contents to form neutrophil extracellular traps. Here we discuss these primordial neutrophil functions, which also play key roles in tissue injury, by providing details of neutrophil cytotoxic functions and congenital disorders of neutrophils. In addition, we present more recent evidence that interactions between neutrophils and adaptive immune cells establish a feed-forward mechanism that amplifies pathologic inflammation. These newly appreciated contributions of neutrophils are described in the setting of several inflammatory and autoimmune diseases.
引用
收藏
页码:181 / 218
页数:38
相关论文
共 265 条
[1]   Mouse neutrophils are professional antigen-presenting cells programmed to instruct Th1 and Th17 T-cell differentiation [J].
Abdallah, Delbert S. Abi ;
Egan, Charlotte E. ;
Butcher, Barbara A. ;
Denkers, Eric Y. .
INTERNATIONAL IMMUNOLOGY, 2011, 23 (05) :317-326
[2]   Leukocyte adhesion deficiency syndrome: a controversy solved [J].
Abram, Clare L. ;
Lowell, Clifford A. .
IMMUNOLOGY AND CELL BIOLOGY, 2009, 87 (06) :440-442
[3]   The Ins and Outs of Leukocyte Integrin Signaling [J].
Abram, Clare L. ;
Lowell, Clifford A. .
ANNUAL REVIEW OF IMMUNOLOGY, 2009, 27 :339-362
[4]   Dendritic Cells Take up and Present Antigens from Viable and Apoptotic Polymorphonuclear Leukocytes [J].
Alfaro, Carlos ;
Suarez, Natalia ;
Onate, Carmen ;
Perez-Gracia, Jose L. ;
Martinez-Forero, Ivan ;
Hervas-Stubbs, Sandra ;
Rodriguez, Inmaculada ;
Perez, Guiomar ;
Bolanos, Elixabet ;
Palazon, Asis ;
Fernandez de Sanmamed, Miguel ;
Morales-Kastresana, Aizea ;
Gonzalez, Alvaro ;
Melero, Ignacio .
PLOS ONE, 2011, 6 (12)
[5]   Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages [J].
Allen, LAH ;
Aderem, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) :627-637
[6]   Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation [J].
Ambruso, DR ;
Knall, C ;
Abell, AN ;
Panepinto, J ;
Kurkchubasche, A ;
Thurman, G ;
Gonzalez-Aller, C ;
Hiester, A ;
deBoer, M ;
Harbeck, RJ ;
Oyer, R ;
Johnson, GL ;
Roos, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (09) :4654-4659
[7]   Neutrophil Function: From Mechanisms to Disease [J].
Amulic, Borko ;
Cazalet, Christel ;
Hayes, Garret L. ;
Metzler, Kathleen D. ;
Zychlinsky, Arturo .
ANNUAL REVIEW OF IMMUNOLOGY, VOL 30, 2012, 30 :459-489
[8]   International Union of Basic and Clinical Pharmacology. LXXXIV: Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions [J].
Back, Magnus ;
Dahlen, Sven-Erik ;
Drazen, Jeffrey M. ;
Evans, Jilly F. ;
Serhan, Charles N. ;
Shimizu, Takao ;
Yokomizo, Takehiko ;
Rovati, G. Enrico .
PHARMACOLOGICAL REVIEWS, 2011, 63 (03) :539-584
[9]   B-lymphocyte activating factor levels are increased in patients with Wegener's granulomatosis and inversely correlated with ANCA titer [J].
Bader, Lucius ;
Koldingsnes, Wenche ;
Nossent, Johannes .
CLINICAL RHEUMATOLOGY, 2010, 29 (09) :1031-1035
[10]   Gp91phox contributes to the development of experimental inflammatory bowel disease [J].
Bao, Shisan ;
Carr, Emma D. J. ;
Xu, Ying-Hua ;
Hunt, Nicholas H. .
IMMUNOLOGY AND CELL BIOLOGY, 2011, 89 (08) :853-860