The roles of Orai and Stim in bone health and disease

被引：16
作者：
Robinson, Lisa J. [1 ,2 ]
Blair, Harry C. [3 ,4 ]
Barnett, John B. [2 ]
Soboloff, Jonathan [5 ,6 ]
机构：
[1] West Virginia Univ, Sch Med, Dept Pathol Anat & Lab Med, Morgantown, WV 26505 USA
[2] West Virginia Univ, Sch Med, Dept Microbiol Immunol & Cell Biol, Morgantown, WV 26505 USA
[3] Vet Affairs Med Ctr, Pittsburgh, PA 15206 USA
[4] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA 15261 USA
[5] Temple Univ, Sch Med, Fels Inst Canc Res & Mol Biol, Philadelphia, PA 19140 USA
[6] Temple Univ, Sch Med, Dept Med Genet & Mol Biochem, Philadelphia, PA 19140 USA
来源：
CELL CALCIUM | 2019年 / 81卷
关键词：
Osteoporosis; Osteogenesis; Mineralization; Bone remodeling; NF-KAPPA-B; LYMPH-NODE ORGANOGENESIS; OSTEOCLAST DIFFERENTIATION; SIGNALING PATHWAYS; MICE LACKING; REGULATES OSTEOCLASTOGENESIS; THERAPEUTIC TARGETS; RECEPTOR ACTIVATOR; CALCIUM-CHANNELS; GENE-EXPRESSION;
D O I：
10.1016/j.ceca.2019.06.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Orai and Slim proteins are the mediators of calcium release-activated calcium signaling and are important in the regulation of bone homeostasis and disease. This includes separate regulatory systems controlling mesenchymal stem cell differentiation to form osteoblasts, which make bone, and differentiation and regulation of osteoclasts, which resorb bone. These systems will be described separately, and their integration and relation to other systems, including Orai and Slim in teeth, will be briefly discussed at the end of this review.
引用
收藏
页码：51 / 58
页数：8
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