Neural Correlates of Overcoming Interference from Instructed and Implemented Stimulus-Response Associations

被引:51
作者
Brass, Marcel [1 ,2 ,3 ]
Wenke, Dorit [3 ,4 ,5 ]
Spengler, Stephanie [3 ]
Waszak, Florian [3 ]
机构
[1] Univ Ghent, Dept Expt Psychol, B-9000 Ghent, Belgium
[2] Univ Ghent, Ghent Inst Funct & Metab Imaging, B-9000 Ghent, Belgium
[3] Max Planck Inst Human Cognit & Brain Sci, D-04103 Leipzig, Germany
[4] UCL, Inst Cognit Neurosci, London WC1N 3AR, England
[5] Univ Paris 05, CNRS, Lab Psychol Percept, F-75006 Paris, France
关键词
verbal instruction; prefrontal cortex; conflict; fMRI; cognitive control; ACC; pre-SMA; ANTERIOR CINGULATE CORTEX; SUPPLEMENTARY MOTOR AREA; MEDIAL FRONTAL-CORTEX; FMRI; CONFLICT; ACTIVATION; DISSOCIATION; COMPONENTS; GOALS;
D O I
10.1523/JNEUROSCI.5259-08.2009
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
One of the major evolutionary advances of human primates in the motor domain is their ability to use verbal instructions to guide their behavior. Despite this fundamental role of verbal information for our behavioral regulation, the functional and neural mechanisms underlying the transformation of verbal instructions into efficient behavior are still poorly understood. To gain deeper insights into the motor representation of verbal instructions, we investigated the neural circuits involved in overcoming interference from stimulus response (S-R) mappings that are merely instructed and S-R mappings that are implemented. Implemented and instructed S-R mappings revealed a partly overlapping pattern of fronto-parietal brain activity when compared with a neutral condition. However, the direct contrast revealed a clear difference with stronger activation for the implemented condition in the ACC, bilateral inferior parietal cortex, the cerebellum and the precentral sulcus. This indicates that instructed S-R mappings share some properties with implemented S-R mappings but that they are lacking the motor-related properties of implemented mappings.
引用
收藏
页码:1766 / 1772
页数:7
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