Human systems immunology: Hypothesis-based modeling and unbiased data-driven approaches

被引：26

作者：

Arazi, Arnon ^{[2
]}

Pendergraft, William F., III ^{[1
,2
,3
,4
]}

Ribeiro, Ruy M. ^{[5
]}

Perelson, Alan S. ^{[5
]}

Hacohen, Nir ^{[1
,2
,3
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Charlestown, MA 02129 USA

[2] Broad Inst MIT & Harvard, Cambridge Ctr 7, Cambridge, MA 02142 USA

[3] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[4] Massachusetts Gen Hosp, Dept Med, Div Nephrol, Boston, MA 02114 USA

[5] Los Alamos Natl Lab, Theoret Biol & Biophys Grp, Los Alamos, NM 87545 USA

来源：

SEMINARS IN IMMUNOLOGY | 2013年 / 25卷 / 03期

关键词：

Systems immunology; Hypothesis-based modeling; Unbiased data-driven approaches; Dynamical modeling; Viral infections; Autoimmunity; DYNAMICS IN-VIVO; GENE-EXPRESSION PROFILES; C VIRUS-REPLICATION; T-CELL VACCINATION; INSULIN SENSITIVITY; LATENT RESERVOIR; HIV-1; INFECTION; IMMUNE-SYSTEM; MINIMAL MODEL; HEPATITIS-B;

D O I：

10.1016/j.smim.2012.11.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Systems immunology is an emerging paradigm that aims at a more systematic and quantitative understanding of the immune system. Two major approaches have been utilized to date in this field: unbiased data-driven modeling to comprehensively identify molecular and cellular components of a system and their interactions; and hypothesis-based quantitative modeling to understand the operating principles of a system by extracting a minimal set of variables and rules underlying them. In this review, we describe applications of the two approaches to the study of viral infections and autoimmune diseases in humans, and discuss possible ways by which these two approaches can synergize when applied to human immunology. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：193 / 200

页数：8

共 115 条

[1] Leukocyte gene expression signatures in antineutrophil cytoplasmic autoantibody and lupus glomerulonephritis [J].

Alcorta, D. A. ;

Barnes, D. A. ;

Dooley, M. A. ;

Sullivan, P. ;

Jonas, B. ;

Liu, Y. ;

Lionaki, S. ;

Reddy, C. B. ;

Chin, H. ;

Dempsey, A. A. ;

Jennette, J. C. ;

Falk, R. J. .

KIDNEY INTERNATIONAL, 2007, 72 (07) :853-864

[2] Strategies to discover regulatory circuits of the mammalian immune system [J].

Amit, Ido ;

Regev, Aviv ;

Hacohen, Nir .

NATURE REVIEWS IMMUNOLOGY, 2011, 11 (12) :873-880

[3] The role of models in understanding CD8+ T-cell memory [J].

Antia, R ;

Ganusov, VV ;

Ahmed, R .

NATURE REVIEWS IMMUNOLOGY, 2005, 5 (02) :101-111

[4] Impact of thymectomy on the peripheral T cell pool in rhesus macaques before and after infection with simian immunodeficiency virus [J].

Arron, ST ;

Ribeiro, RM ;

Gettie, A ;

Bohm, R ;

Blanchard, J ;

Yu, J ;

Perelson, AS ;

Hol, DD ;

Zhang, LQ .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2005, 35 (01) :46-55

[5] Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission [J].

Arthur, Ariel T. ;

Armati, Patricia J. ;

Bye, Chris ;

Heard, Robert N. S. ;

Stewart, Graeme J. ;

Pollard, John D. ;

Booth, David R. .

BMC MEDICAL GENETICS, 2008, 9

[6] Lymphocyte kinetics: the interpretation of labelling data [J].

Asquith, B ;

Debacq, C ;

Macallan, DC ;

Willems, L ;

Bangham, CRM .

TRENDS IN IMMUNOLOGY, 2002, 23 (12) :596-601

[7] Kinetics of influenza A virus infection in humans [J].

Baccam, Prasith ;

Beauchemin, Catherine ;

Macken, Catherine A. ;

Hayden, Frederick G. ;

Perelson, Alan S. .

JOURNAL OF VIROLOGY, 2006, 80 (15) :7590-7599

[8] Interferon and granulopoiesis signatures in systemic lupus erythematosus blood [J].

Bennett, L ;

Palucka, AK ;

Arce, E ;

Cantrell, V ;

Borvak, J ;

Banchereau, J ;

Pascual, V .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (06) :711-723

[9] A Plaidoyer for 'systems immunology' [J].

Benoist, C ;

Germain, RN ;

Mathis, D .

IMMUNOLOGICAL REVIEWS, 2006, 210 :229-234

[10] PHYSIOLOGIC EVALUATION OF FACTORS CONTROLLING GLUCOSE-TOLERANCE IN MAN - MEASUREMENT OF INSULIN SENSITIVITY AND BETA-CELL GLUCOSE SENSITIVITY FROM THE RESPONSE TO INTRAVENOUS GLUCOSE [J].

BERGMAN, RN ;

PHILLIPS, LS ;

COBELLI, C .

JOURNAL OF CLINICAL INVESTIGATION, 1981, 68 (06) :1456-1467

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