A new approach to the synthesis of di- and tripeptides with unnatural amino acids using organozinc chemistry

被引：14

作者：

Dunn, MJ ^{[1
]}

Jackson, RFW ^{[1
]}

机构：

[1] UNIV NEWCASTLE UPON TYNE,DEPT CHEM,NEWCASTLE TYNE NE1 7RU,TYNE & WEAR,ENGLAND

来源：

TETRAHEDRON | 1997年 / 53卷 / 40期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4020(97)00879-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Di- and tripeptides which incorporate an iodoalanine unit at the C-terminus can be converted into the corresponding organozinc reagents upon treatment with activated zinc. These C-terminal di-and tripeptide organozinc reagents react with electrophiles either under palladium catalysis, or by prior transmetallation to a zinc/copper reagent, to give di-and tripeptides incorporating non-proteinogenic amino acids without loss of stereochemical purity. (C) 1997 Elsevier Science Ltd.

引用

页码：13905 / 13914

页数：10

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