CircR2Disease: a manually curated database for experimentally supported circular RNAs associated with various diseases

被引：191
作者：
Fan, Chunyan [1 ]
Lei, Xiujuan [1 ]
Fang, Zengqiang [1 ]
Jiang, Qinghua [2 ]
Wu, Fang-Xiang [3 ,4 ]
机构：
[1] Shaanxi Normal Univ, Sch Comp Sci, Xian 710119, Shaanxi, Peoples R China
[2] Harbin Inst Technol, Sch Comp Sci & Technol, Ctr Bioinformat, Harbin 150001, Heilongjiang, Peoples R China
[3] Univ Saskatchewan, Dept Mech Engn, Saskatoon, SK S7N 5A9, Canada
[4] Univ Saskatchewan, Div Biomed Engn, Saskatoon, SK S7N 5A9, Canada
来源：
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION | 2018年
基金：
中国国家自然科学基金;
关键词：
MICRORNA; CERNA; V2.0;
D O I：
10.1093/database/bay044
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
CircR2Disease is a manually curated database, which provides a comprehensive resource for circRNA deregulation in various diseases. Increasing evidences have shown that circRNAs play critical roles in transcriptional, post-transcriptional and translational regulation. Therefore, the aberrant expression of circRNAs has been associated with a group of diseases. It is significant to develop a high-quality database to deposit the deregulated circRNAs in diseases. The current version of CircR2Disease contains 725 associations between 661 circRNAs and 100 diseases by reviewing existing literatures. Each entry in the CircR2Disease contains detailed information for the circRNA-disease relationship, including circRNA name, coordinates and gene symbol, disease name, expression patterns of circRNA, experimental techniques, a brief description of the circRNA-disease relationship, year of publication and the PubMed ID. CircR2Disease provides a user-friendly interface to browse, search and download as well as to submit novel disease-related circRNAs. CircR2Disease could be very beneficial for researches to investigate the mechanism of disease-related circRNAs and explore the appropriate algorithms for predicting novel associations.
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页数：6
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