Acrobatic exercise recovers object recognition memory impairment in hypoxic-ischemic rats

被引：5

作者：

de Almeida, Wellington ^{[1
,2
]}

Confortim, Heloisa Deola ^{[1
,3
]}

Deniz, Bruna Ferrary ^{[1
,2
]}

Miguel, Patricia Maidana ^{[1
,2
]}

Vieira, Milene Cardoso ^{[2
]}

Bronauth, Loise ^{[2
]}

dos Santos, Adriana Souza ^{[1
,2
]}

Bertoldi, Karine ^{[4
]}

Siqueira, Ionara Rodrigues ^{[4
,5
]}

Pereira, Lenir Orlandi ^{[1
,2
]}

机构：

[1] Univ Fed Rio Grande do Sul, Programa Posgrad Neurociencias, Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Dept Ciencias Morfol, Porto Alegre, RS, Brazil

[3] UNIVEL Ctr Univ, Cascavel, Brazil

[4] Univ Fed Rio Grande do Sul, Dept Farmacol, Porto Alegre, RS, Brazil

[5] Univ Fed Rio Grande do Sul, Fisiol, Programa Posgrad Ciencias Biol, Porto Alegre, RS, Brazil

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 2021年 / 81卷 / 01期

关键词：

coordination training; developmental brain disorder; motor skill learning; neural development; perinatal asphyxia; DAILY ENVIRONMENTAL ENRICHMENT; BRAIN-DAMAGE; PERINATAL ASPHYXIA; TRAINING PROMOTES; PYRAMIDAL NEURONS; MOTOR CORTEX; HIPPOCAMPUS; PLASTICITY; BDNF; STRIATUM;

D O I：

10.1002/jdn.10075

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neonatal hypoxia-ischemia (HI) can lead to cognitive impairments and motor dysfunction. Acrobatic exercises (AE) were proposing as therapeutic option to manage HI motor deficits, however, the cognitive effects after this treatment are still poorly understood. Therefore, we evaluated the effects of AE protocol on memory impairments and brain plasticity markers after Rice-Vannucci HI rodent model. Wistar rats on the 7th postnatal day (PND) were submitted to HI model and after weaning (PND22) were trained for 5 weeks with AE protocol, then subsequently submitted to cognitive tests. Our results showed recovery in novel object recognition (NOR) memory, but not, spatial Morris Water Maze (WM) memory after AE treatment in HI rats. BDNF and synaptophysin neuroplasticity markers indicate plastic alterations in the hippocampus and striatum, with maintenance of synaptophysin despite the reduction of total volume tissue, besides, hippocampal HI-induced ipsilateral BDNF increased, and striatum contralateral BDNF decreased were noted. Nevertheless, the exercise promoted functional recovery and seems to be a promising strategy for HI treatment, however, future studies identifying neuroplastic pathway for this improvement are needed.

引用

页码：60 / 70

页数：11

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