Continuous-Flow Electrosynthesis of Benzofused S-Heterocycles by Dehydrogenative C-S Cross-Coupling

被引：99

作者：

Huang, Chong ^{[1
,2
]}

Qian, Xiang-Yang ^{[1
,2
]}

Xu, Hai-Chao ^{[1
,2
]}

机构：

[1] Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, IChEM, Xiamen 361005, Fujian, Peoples R China

[2] Xiamen Univ, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2019年 / 58卷 / 20期

关键词：

C-H functionalization; electrochemistry; flow chemistry; heterocycles; radicals; MICROFLOW ELECTROLYSIS CELL; BOND FORMATION; ORGANIC ELECTROCHEMISTRY; H FUNCTIONALIZATION; THIAZOLOPYRIDINES; BENZOTHIAZOLES; THIOLATION; STRATEGIES; OXIDATION; LIBRARY;

D O I：

10.1002/anie.201901610

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reported herein is the synthesis of benzofused six-membered S-heterocycles by intramolecular dehydrogenative C-S coupling using a modular flow electrolysis cell. The continuous-flow electrosynthesis not only ensures efficient product formation, but also obviates the need for transition-metal catalysts, oxidizing reagents, and supporting electrolytes. Reaction scale-up is conveniently achieved through extended electrolysis without changing the reaction conditions and equipment.

引用

页码：6650 / 6653

页数：4

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