Towards curative therapy in gastric cancer: Faraway, so close!

被引：10

作者：

Cravo, Marilia ^{[1
,2
]}

Fidalgo, Catarina ^{[1
,2
]}

Garrido, Rita ^{[1
,2
]}

Rodrigues, Tania ^{[1
,2
]}

Luz, Goncalo ^{[1
,2
]}

Palmela, Carolina ^{[1
,2
]}

Santos, Marta ^{[1
,2
]}

Lopes, Fabio ^{[1
,2
]}

Maio, Rui ^{[1
,2
]}

机构：

[1] Hosp Beatriz Angelo, Dept Gastroenterol, Surg Clin, P-2674514 Loures, Portugal

[2] Hosp Beatriz Angelo, Dept Gastroenterol, Oncol Clin, P-2674514 Loures, Portugal

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2015年 / 21卷 / 41期

关键词：

Gastric cancer; Multidisciplinary treatment; Therapeutic strategies; Curative surgery; LYMPH-NODE DISSECTION; RANDOMIZED CLINICAL-TRIAL; OPEN DISTAL GASTRECTOMY; LAPAROSCOPIC TOTAL GASTRECTOMY; PHASE-III TRIAL; PERIOPERATIVE CHEMOTHERAPY; NEOADJUVANT CHEMOTHERAPY; D2; LYMPHADENECTOMY; PATIENT SURVIVAL; D-2; RESECTIONS;

D O I：

10.3748/wjg.v21.i41.11609

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Although recent diagnostic and therapeutic advances have substantially improved the survival of patients with gastric cancer (GC), the overall prognosis is still poor. Surgery is the only curative treatment and should be performed in experienced centers. Due to high relapse following surgery, complementary and systemic treatment aimed at eradicating micrometastasis should be performed in most cases. Cytotoxic treatments are effective in downstaging locally advanced cancer, but different sensitivities and toxicities probably exist in different GC subtypes. Current treatment protocols are based primarily on clinical data and histological features, but molecular biomarkers that would allow for the prediction of treatment responses are urgently needed. Understanding how host factors are responsible for inter-individual variability of drug response or toxicity will also contribute to the development of more effective and less toxic treatments.

引用

页码：11609 / 11620

页数：12

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