Towards curative therapy in gastric cancer: Faraway, so close!

被引:10
作者
Cravo, Marilia [1 ,2 ]
Fidalgo, Catarina [1 ,2 ]
Garrido, Rita [1 ,2 ]
Rodrigues, Tania [1 ,2 ]
Luz, Goncalo [1 ,2 ]
Palmela, Carolina [1 ,2 ]
Santos, Marta [1 ,2 ]
Lopes, Fabio [1 ,2 ]
Maio, Rui [1 ,2 ]
机构
[1] Hosp Beatriz Angelo, Dept Gastroenterol, Surg Clin, P-2674514 Loures, Portugal
[2] Hosp Beatriz Angelo, Dept Gastroenterol, Oncol Clin, P-2674514 Loures, Portugal
关键词
Gastric cancer; Multidisciplinary treatment; Therapeutic strategies; Curative surgery; LYMPH-NODE DISSECTION; RANDOMIZED CLINICAL-TRIAL; OPEN DISTAL GASTRECTOMY; LAPAROSCOPIC TOTAL GASTRECTOMY; PHASE-III TRIAL; PERIOPERATIVE CHEMOTHERAPY; NEOADJUVANT CHEMOTHERAPY; D2; LYMPHADENECTOMY; PATIENT SURVIVAL; D-2; RESECTIONS;
D O I
10.3748/wjg.v21.i41.11609
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Although recent diagnostic and therapeutic advances have substantially improved the survival of patients with gastric cancer (GC), the overall prognosis is still poor. Surgery is the only curative treatment and should be performed in experienced centers. Due to high relapse following surgery, complementary and systemic treatment aimed at eradicating micrometastasis should be performed in most cases. Cytotoxic treatments are effective in downstaging locally advanced cancer, but different sensitivities and toxicities probably exist in different GC subtypes. Current treatment protocols are based primarily on clinical data and histological features, but molecular biomarkers that would allow for the prediction of treatment responses are urgently needed. Understanding how host factors are responsible for inter-individual variability of drug response or toxicity will also contribute to the development of more effective and less toxic treatments.
引用
收藏
页码:11609 / 11620
页数:12
相关论文
共 94 条
[1]   Proteomic and metabolic prediction of response to therapy in gastric cancer [J].
Aichler, Michaela ;
Luber, Birgit ;
Lordick, Florian ;
Walch, Axel .
WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (38) :13648-13657
[2]   Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials [J].
Algra, Annemijn M. ;
Rothwell, Peter M. .
LANCET ONCOLOGY, 2012, 13 (05) :518-527
[3]   Microsatellite instability in sporadic gastric cancer: its prognostic role and guidance for 5-FU based chemotherapy after R0 resection [J].
An, Ji Yeong ;
Kim, Hyunki ;
Cheong, Jae-Ho ;
Hyung, Woo Jin ;
Kim, Hoguen ;
Noh, Sung Hoon .
INTERNATIONAL JOURNAL OF CANCER, 2012, 131 (02) :505-511
[4]   A randomized phase III study of adjuvant platinum/docetaxel chemotherapy with or without radiation therapy in patients with gastric cancer [J].
Bamias, Aristotelis ;
Karina, M. ;
Papakostas, P. ;
Kostopoulos, I. ;
Bobos, M. ;
Vourli, G. ;
Samantas, E. ;
Christodoulou, Ch. ;
Pentheroudakis, G. ;
Pectasides, D. ;
Dimopoulos, M. A. ;
Fountzilas, G. .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2010, 65 (06) :1009-1021
[5]   Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial [J].
Bang, Yung-Jue ;
Kim, Young-Woo ;
Yang, Han-Kwang ;
Chung, Hyun Cheol ;
Park, Young-Kyu ;
Lee, Kyung Hee ;
Lee, Keun-Wook ;
Kim, Yong Ho ;
Noh, Sang-Ik ;
Cho, Jae Yong ;
Mok, Young Jae ;
Kim, Yeul Hong ;
Ji, Jiafu ;
Yeh, Ta-Sen ;
Button, Peter ;
Sirzen, Florin ;
Noh, Sung Hoon .
LANCET, 2012, 379 (9813) :315-321
[6]   Comprehensive molecular characterization of gastric adenocarcinoma [J].
Bass, Adam J. ;
Thorsson, Vesteinn ;
Shmulevich, Ilya ;
Reynolds, Sheila M. ;
Miller, Michael ;
Bernard, Brady ;
Hinoue, Toshinori ;
Laird, Peter W. ;
Curtis, Christina ;
Shen, Hui ;
Weisenberger, Daniel J. ;
Schultz, Nikolaus ;
Shen, Ronglai ;
Weinhold, Nils ;
Keiser, David P. ;
Bowlby, Reanne ;
Sipahimalani, Payal ;
Cherniack, Andrew D. ;
Getz, Gad ;
Liu, Yingchun ;
Noble, Michael S. ;
Pedamallu, Chandra ;
Sougnez, Carrie ;
Taylor-Weiner, Amaro ;
Akbani, Rehan ;
Lee, Ju-Seog ;
Liu, Wenbin ;
Mills, Gordon B. ;
Yang, Da ;
Zhang, Wei ;
Pantazi, Angeliki ;
Parfenov, Michael ;
Gulley, Margaret ;
Piazuelo, M. Blanca ;
Schneider, Barbara G. ;
Kim, Jihun ;
Boussioutas, Alex ;
Sheth, Margi ;
Demchok, John A. ;
Rabkin, Charles S. ;
Willis, Joseph E. ;
Ng, Sam ;
Garman, Katherine ;
Beer, David G. ;
Pennathur, Arjun ;
Raphael, Benjamin J. ;
Wu, Hsin-Ta ;
Odze, Robert ;
Kim, Hark K. ;
Bowen, Jay .
NATURE, 2014, 513 (7517) :202-209
[7]  
Boige V, 2007, ASCO M, V25, P4510, DOI DOI 10.1200/jco.2007.25.18_suppl.4510
[8]   RANDOMIZED COMPARISON OF MORBIDITY AFTER D1 AND D2 DISSECTION FOR GASTRIC-CANCER IN 996 DUTCH PATIENTS [J].
BONENKAMP, JJ ;
SONGUN, I ;
HERMANS, J ;
SASAKO, M ;
WELVAART, K ;
PLUKKER, JTM ;
VANELK, P ;
OBERTOP, H ;
GOUMA, DJ ;
TAAT, CW ;
VANLANSCHOT, J ;
MEYER, S ;
DEGRAAF, PW ;
VONMEYENFELDT, MF ;
TILANUS, H ;
VANDEVELDE, CJH .
LANCET, 1995, 345 (8952) :745-748
[9]   Extended lymph-node dissection for gastric cancer [J].
Bonenkamp, JJ ;
Hermans, J ;
Sasako, M ;
van de Velde, CJH .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (12) :908-914
[10]   Total versus subtotal gastrectomy - Surgical morbidity and mortality rates in a multicenter Italian randomized trial [J].
Bozzetti, F ;
Marubini, E ;
Bonfanti, G ;
Miceli, R ;
Piano, C ;
Crose, N ;
Gennari, L .
ANNALS OF SURGERY, 1997, 226 (05) :613-620