Objectives/HypothesisDetermine the incremental health care costs associated with the diagnosis and treatment of acute otitis media (AOM) in children. Study DesignCross-sectional analysis of a national health-care cost database. MethodsPediatric patients (age<18 years) were examined from the 2009 Medical Expenditure Panel Survey. From the linked medical conditions file, cases with a diagnosis of AOM were extracted, along with comorbid conditions. Ambulatory visit rates, prescription refills, and ambulatory health care costs were then compared between children with and without a diagnosis of AOM, adjusting for age, sex, region, race, ethnicity, insurance coverage, and Charlson comorbidity Index. ResultsA total of 8.70.4 million children were diagnosed with AOM (10.70.4% annually, mean age 5.3 years, 51.3% male) among 81.5 +/- 2.3 million children sampled (mean age 8.9 years, 51.3% male). Children with AOM manifested an additional +2.0 office visits, +0.2 emergency department visits, and +1.6 prescription fills (all P <0.001) per year versus those without AOM, adjusting for demographics and medical comorbidities. Similarly, AOM was associated with an incremental increase in outpatient health care costs of $314 per child annually (P <0.001) and an increase of $17 in patient medication costs (P <0.001), but was not associated with an increase in total prescription expenses ($13, P=0.766). ConclusionsThe diagnosis of AOM confers a significant incremental health-care utilization burden on both patients and the health care system. With its high prevalence across the United States, pediatric AOM accounts for approximately $2.88 billion in added health care expense annually and is a significant health-care utilization concern. Level of Evidence2C. Laryngoscope, 124:301-305, 2014