Fracture repair in the elderly: Clinical and experimental considerations

被引：23
作者：
Meinberg, E. G. [1 ]
Clark, D. [1 ]
Miclau, K. R. [1 ]
Marcucio, R. [1 ]
Miclau, T. [1 ]
机构：
[1] Zuckerberg San Francisco Gen Hosp, UCSF ZSFG Orthopaed Trauma Inst, UCSF Dept Orthopaed Surg, Orthopaed Trauma Inst, San Francisco, CA USA
来源：
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED | 2019年 / 50卷
关键词：
Fracture; Repair; Elderly; Clinical; Healing; AGE-RELATED-CHANGES; FEMORAL-NECK; STEM-CELLS; MOLECULAR ASPECTS; BONE-FORMATION; BLOOD-FLOW; EXPRESSION; MACROPHAGES; MARROW; ANGIOGENESIS;
D O I：
10.1016/j.injury.2019.05.005
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Fractures in the elderly represent a significant and rising socioeconomic problem. Although aging has been associated with delays in healing, there is little direct clinical data isolating the effects of aging on bone healing from the associated comorbidities that are frequently present in elderly populations. Basic research has demonstrated that all of the components of fracture repair-cells, extracellular matrix, blood supply, and molecules and their receptors-are negatively impacted by the aging process, which likely explains poorer clinical outcomes. Improved understanding of age-related fracture healing should aid in the development of novel treatment strategies, technologies, and therapies to improve bone repair in elderly patients. (C) 2019 Elsevier Ltd. All rights reserved.
引用
收藏
页码：S62 / S65
页数：4
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