Objective: To study the protective role of saliva on brain of rats with septic shock. Methods: 30 rats were randomly divided into three groups: control group(n=6), septic shock group(n=12), salvia group(n=12), each group has two time points: 6h and 12h, each time point 6 mouse. The mouse in the septic shock and treatment groups were established the models of tail intravenous endotoxin in 5mg/kg doses, in the salvia group when the rats appeared shock signs intraperitoneal injection of salvia in 5ml/kg doses immediately, And the mouse in the control group were only injected amount saline. After surgery all the rats were partial anesthesiaed and eye removal to take the blood to detect the concentration of NSE, then break aged the mouse to get the brain to detect the concentration of NO. 6 mice of each group were executed to extract the sample for the pathological section at the different time points, and the sections were stained with Hematoxylin and Eosin and TdT-mediated dUTP nick end labeling. The results: Compared with that in the control group, neurons in hippocampal CA1 region damage obviously and a large number of TUNEL-positive cells were seen in the septic shock group, the level of NSE and NO increased significantly (P<0. 01=. The Salvia group can significantly reduce the change. Conclusion: Salvia can reduce the brain damage with septic shock and apoptosis in neurons of hippocampal region; the mechanism may be connected with the inhibition of excessive NO.
