The beneficial effect of donepezil on visual hallucinations in three patients with Parkinson's disease

被引：38
作者：
Kurita, A
Ochiai, Y
Kono, Y
Suzuki, M
Inoue, K
机构：
[1] Jikei Univ, Sch Med, Dept Neurol, Minato Ku, Tokyo 1058461, Japan
[2] Jikei Univ, Sch Med, Dept Psychiat, Tokyo 1058461, Japan
来源：
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY | 2003年 / 16卷 / 03期
关键词：
Parkinson's disease; acetylcholinesterese inhibitor; donepezil; visual hallucinations; cognitive impairment; motor functions;
D O I：
10.1177/0891988703256054
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Visual hallucinations (VHs) are common psychiatric symptoms in patients with long-standing Parkinson's disease (PD). Treatment with neuroleptics or withdrawal of anti-PD drugs may improve VHs but will worsen motor dysfunctions. The authors report on 3 patients with long-standing PD who were treated with the cholinesterase inhibitor donepezil for the treatment of VHs. Each received a daily dose of 5 mg of donepezil, after reducing or discontinuing anti-PD medications had failed to relieve the VHs. In 2 patients (patient 1, 2), donepezil decreased VHs without worsening motor dysfunctions. In addition, the cognitive status of patient 2 improved. In patient 3, donepezil also resolved VHs, but delusions developed during treatment. After discontinuing donepezil, delusions disappeared and VHs reappeared. Donepezil may ameliorate visual hallucinations in PD patients, but controlled, double-blind trials are necessary to further clarify the effect of this drug on VHs in PD.
引用
收藏
页码：184 / 188
页数：5
相关论文
共 24 条
[1]   Parkinson disease neuropathology - Later-developing dementia and loss of the levodopa response [J].
Apaydin, H ;
Ahlskog, JE ;
Parisi, JE ;
Boeve, BF ;
Dickson, DW .
ARCHIVES OF NEUROLOGY, 2002, 59 (01) :102-112
[2]   Hallucinations, REM sleep, and Parkinson's disease - A medical hypothesis [J].
Arnulf, I ;
Bonnet, AM ;
Damier, P ;
Bejjani, BP ;
Seilhean, D ;
Derenne, JP ;
Agid, Y .
NEUROLOGY, 2000, 55 (02) :281-288
[3]   Successful use of donepezil for the treatment of psychotic symptoms in patients with Parkinson's disease [J].
Bergman, J ;
Lerner, V .
CLINICAL NEUROPHARMACOLOGY, 2002, 25 (02) :107-110
[4]   REM sleep behavior disorder and degenerative dementia - An association likely reflecting Lewy body disease [J].
Boeve, BF ;
Silber, MH ;
Ferman, TJ ;
Kokmen, E ;
Smith, GE ;
Ivnik, RJ ;
Parisi, JE ;
Olson, EJ ;
Petersen, RC .
NEUROLOGY, 1998, 51 (02) :363-370
[5]   Cholinesterase inhibitors: A new class of psychotropic compounds [J].
Cummings, JL .
AMERICAN JOURNAL OF PSYCHIATRY, 2000, 157 (01) :4-15
[6]   Donepezil in the treatment of hallucinations and delusions in Parkinson's disease [J].
Fabbrini, G ;
Barbanti, P ;
Aurilia, C ;
Pauletti, C ;
Lenzi, GL ;
Meco, G .
NEUROLOGICAL SCIENCES, 2002, 23 (01) :41-43
[7]  
Fahn S., RECENT DEV PARKINSON, V2, P153, DOI DOI 10.1002/ANA.410220556
[8]   MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].
FOLSTEIN, MF ;
FOLSTEIN, SE ;
MCHUGH, PR .
JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198
[9]   RISPERIDONE IN PARKINSONS-DISEASE [J].
FORD, B ;
LYNCH, T ;
GREENE, P .
LANCET, 1994, 344 (8923) :681-681
[10]   RISK-FACTORS FOR NURSING-HOME PLACEMENT IN ADVANCED PARKINSONS-DISEASE [J].
GOETZ, CG ;
STEBBINS, GT .
NEUROLOGY, 1993, 43 (11) :2227-2229
123