5α-reduced androgens may have actions in the hippocampus to enhance cognitive performance of male rats

被引:76
作者
Frye, CA
Edinger, KL
Seliga, AM
Wawrzycki, JM
机构
[1] SUNY Albany, Dept Psychol, Albany, NY 12222 USA
[2] SUNY Albany, Dept Sci Biol, Albany, NY 12222 USA
[3] SUNY Albany, Ctr Res Neurosci, Albany, NY 12222 USA
关键词
androgens; nongenomic; gaba; androgen receptors; cognitive; mnemonic;
D O I
10.1016/j.psyneuen.2003.10.004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Androgens may improve cognitive performance; however, these effects and mechanisms of androgens are not well understood. Whether testosterone's (T) effects on cognitive performance are mediated by its 5alpha-reduced, non-aromatizable metabolite dihydrotestosterone (DHT) and/or its 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) reduced metabolite 3alpha-androstanediot (3alpha-diol), was investigated. In Experiment 1, male rats that were gonadally intact, or gonadectomized (GDX) and DHT-replaced with a silastic capsule, had better performance in the inhibitory avoidance task, and higher plasma DHT and 3alpha-diol levels, compared to GDX rats. In Experiments 2-4, intra-hippocampal indomethacin, a 3alpha-HSD inhibitor, to intact or DHT-replaced, but not GDX, rats decreased performance in the inhibitory avoidance task and reduced hippocampal 3alpha-diol levels compared to that observed in rats with control implants. Thus, the 5alpha-reduced androgen DHT has cognitive-enhancing effects, independent of E-2, which are attenuated by a 3alpha-HSD inhibitor, indomethacin. These results suggest that 5alpha-reduced androgens may have actions in the hippocampus to improve cognitive performance. V 2003 Elsevier Ltd. All. rights reserved.
引用
收藏
页码:1019 / 1027
页数:9
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