Prediction;
Ultra-high risk (UHR);
Children and adolescents;
Early-onset psychosis;
CLINICAL HIGH-RISK;
SCHIZOPHRENIA SPECTRUM DISORDERS;
MENTAL STATE;
YOUNG-PEOPLE;
BASE-LINE;
INDICATED PREVENTION;
UNTREATED PSYCHOSIS;
COMMUNITY SAMPLE;
1ST EPISODE;
EARLY-ONSET;
D O I:
10.1016/j.schres.2015.10.033
中图分类号:
R749 [精神病学];
学科分类号:
100205 ;
摘要:
Objective: The validity of current ultra-high risk (UHR) criteria is under-examined in help-seeking minors, particularly, in children below the age of 12 years. Thus, the present study investigated predictors of one-year outcome in children and adolescents (CAD) with UHR status. Method: Thirty-five children and adolescents (age 9-17 years) meeting UHR criteria according to the Structured Interview for Psychosis-Risk Syndromes were followed-up for 12 months. Regression analyses were employed to detect baseline predictors of conversion to psychosis and of outcome of non-converters (remission and persistence of UHR versus conversion). Results: At one-year follow-up, 20% of patients had developed schizophrenia, 25.7% had remitted from their UHR status that, consequently, had persisted in 54.3%. No patient had fully remitted from mental disorders, even if UHR status was not maintained. Conversion was best predicted by any transient psychotic symptom and a disorganized communication score. No prediction model for outcome beyond conversion was identified. Conclusions: Our findings provide the first evidence for the predictive utility of UHR criteria in CAD in terms of brief intermittent psychotic symptoms (BIPS) when accompanied by signs of cognitive impairment, i.e. disorganized communication. However, because attenuated psychotic symptoms (APS) related to thought content and perception were indicative of non-conversion at 1-year follow-up, their use in early detection of psychosis in CAD needs further study. Overall, the need for more in-depth studies into developmental peculiarities in the early detection and treatment of psychoses with an onset of illness in childhood and early adolescence was further highlighted. (C) 2015 Elsevier B.V. All rights reserved.
机构:
North Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
North Shore Long Isl Jewish Hlth Syst, Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY USANorth Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
Carrion, Ricardo E.
McLaughlin, Danielle
论文数: 0引用数: 0
h-index: 0
机构:
North Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USANorth Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
McLaughlin, Danielle
Goldberg, Terry E.
论文数: 0引用数: 0
h-index: 0
机构:
North Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
North Shore Long Isl Jewish Hlth Syst, Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY USANorth Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
Goldberg, Terry E.
Auther, Andrea M.
论文数: 0引用数: 0
h-index: 0
机构:
North Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USANorth Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
Auther, Andrea M.
Olsen, Ruth H.
论文数: 0引用数: 0
h-index: 0
机构:
North Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USANorth Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
Olsen, Ruth H.
Olvet, Doreen M.
论文数: 0引用数: 0
h-index: 0
机构:
North Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
North Shore Long Isl Jewish Hlth Syst, Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY USANorth Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
Olvet, Doreen M.
Correll, Christoph U.
论文数: 0引用数: 0
h-index: 0
机构:
North Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
North Shore Long Isl Jewish Hlth Syst, Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY USA
Hofstra North Shore LIJ Sch Med, Dept Psychiat & Mol Med, Hempstead, NY USANorth Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
Correll, Christoph U.
Cornblatt, Barbara A.
论文数: 0引用数: 0
h-index: 0
机构:
North Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
North Shore Long Isl Jewish Hlth Syst, Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY USA
Hofstra North Shore LIJ Sch Med, Dept Psychiat & Mol Med, Hempstead, NY USANorth Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
机构:
Columbia Univ, New York State Psychiat Inst, New York, NY 10032 USA
Columbia Univ, Sch Social Work, New York, NY USAColumbia Univ, New York State Psychiat Inst, New York, NY 10032 USA
DeVylder, Jordan E.
Muchomba, Felix M.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Sch Social Work, New York, NY USAColumbia Univ, New York State Psychiat Inst, New York, NY 10032 USA
Muchomba, Felix M.
Gill, Kelly E.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, New York State Psychiat Inst, New York, NY 10032 USAColumbia Univ, New York State Psychiat Inst, New York, NY 10032 USA
Gill, Kelly E.
Ben-David, Shelly
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, New York State Psychiat Inst, New York, NY 10032 USAColumbia Univ, New York State Psychiat Inst, New York, NY 10032 USA
Ben-David, Shelly
Walder, Deborah J.
论文数: 0引用数: 0
h-index: 0
机构:
CUNY Brooklyn Coll, Dept Psychol, Brooklyn, NY 11210 USA
CUNY, Grad Ctr, New York, NY USAColumbia Univ, New York State Psychiat Inst, New York, NY 10032 USA
Walder, Deborah J.
Malaspina, Dolores
论文数: 0引用数: 0
h-index: 0
机构:
New York Off Mental Hlth, Creedmoor Psychiat Ctr, New York, NY USA
NYU, Dept Psychiat, New York, NY 10016 USAColumbia Univ, New York State Psychiat Inst, New York, NY 10032 USA
Malaspina, Dolores
Corcoran, Cheryl M.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, New York State Psychiat Inst, New York, NY 10032 USAColumbia Univ, New York State Psychiat Inst, New York, NY 10032 USA
机构:
North Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
North Shore Long Isl Jewish Hlth Syst, Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY USANorth Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
Carrion, Ricardo E.
McLaughlin, Danielle
论文数: 0引用数: 0
h-index: 0
机构:
North Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USANorth Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
McLaughlin, Danielle
Goldberg, Terry E.
论文数: 0引用数: 0
h-index: 0
机构:
North Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
North Shore Long Isl Jewish Hlth Syst, Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY USANorth Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
Goldberg, Terry E.
Auther, Andrea M.
论文数: 0引用数: 0
h-index: 0
机构:
North Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USANorth Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
Auther, Andrea M.
Olsen, Ruth H.
论文数: 0引用数: 0
h-index: 0
机构:
North Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USANorth Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
Olsen, Ruth H.
Olvet, Doreen M.
论文数: 0引用数: 0
h-index: 0
机构:
North Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
North Shore Long Isl Jewish Hlth Syst, Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY USANorth Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
Olvet, Doreen M.
Correll, Christoph U.
论文数: 0引用数: 0
h-index: 0
机构:
North Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
North Shore Long Isl Jewish Hlth Syst, Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY USA
Hofstra North Shore LIJ Sch Med, Dept Psychiat & Mol Med, Hempstead, NY USANorth Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
Correll, Christoph U.
Cornblatt, Barbara A.
论文数: 0引用数: 0
h-index: 0
机构:
North Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
North Shore Long Isl Jewish Hlth Syst, Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY USA
Hofstra North Shore LIJ Sch Med, Dept Psychiat & Mol Med, Hempstead, NY USANorth Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
机构:
Columbia Univ, New York State Psychiat Inst, New York, NY 10032 USA
Columbia Univ, Sch Social Work, New York, NY USAColumbia Univ, New York State Psychiat Inst, New York, NY 10032 USA
DeVylder, Jordan E.
Muchomba, Felix M.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Sch Social Work, New York, NY USAColumbia Univ, New York State Psychiat Inst, New York, NY 10032 USA
Muchomba, Felix M.
Gill, Kelly E.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, New York State Psychiat Inst, New York, NY 10032 USAColumbia Univ, New York State Psychiat Inst, New York, NY 10032 USA
Gill, Kelly E.
Ben-David, Shelly
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, New York State Psychiat Inst, New York, NY 10032 USAColumbia Univ, New York State Psychiat Inst, New York, NY 10032 USA
Ben-David, Shelly
Walder, Deborah J.
论文数: 0引用数: 0
h-index: 0
机构:
CUNY Brooklyn Coll, Dept Psychol, Brooklyn, NY 11210 USA
CUNY, Grad Ctr, New York, NY USAColumbia Univ, New York State Psychiat Inst, New York, NY 10032 USA
Walder, Deborah J.
Malaspina, Dolores
论文数: 0引用数: 0
h-index: 0
机构:
New York Off Mental Hlth, Creedmoor Psychiat Ctr, New York, NY USA
NYU, Dept Psychiat, New York, NY 10016 USAColumbia Univ, New York State Psychiat Inst, New York, NY 10032 USA
Malaspina, Dolores
Corcoran, Cheryl M.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, New York State Psychiat Inst, New York, NY 10032 USAColumbia Univ, New York State Psychiat Inst, New York, NY 10032 USA