An improved and practical synthesis of Fmoc Rink linker

被引：0

作者：

Qin, Ling-yan ^{[1
]}

Zhu, Hao-ting ^{[1
]}

Zhan, Li ^{[1
]}

Zhu, Yong ^{[2
]}

Luo, Yu ^{[1
]}

机构：

[1] East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China

[2] Suzhou Highfine Biotech Co Ltd, Suzhou 215129, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH | 2019年 / 43卷 / 3-4期

关键词：

Rink linker; solid-phase peptide synthesis; combinatorial chemistry; SOLID-PHASE SYNTHESIS; REDUCTION; PEPTIDES; OXIMES; AGENTS; RESIN; ACID;

D O I：

10.1177/1747519819836490

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fmoc Rink linker is a widely used peptide-resin linker in the solid-phase synthesis of peptide-amides. This paper describes an improved and practical eight-step synthetic approach for this compound in a 50% overall yield, using p-hydroxybenzaldehyde as the starting material. The procedure is operationally simple and amenable to scale-up synthesis.

引用

页码：81 / 85

页数：5

共 22 条

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