Effects of Aging on Renal Function and Regenerative Capacity

被引：27
作者：
Abdel-Rahman, Emaad M. [1 ]
Okusa, Mark D. [1 ]
机构：
[1] Univ Virginia Hlth Syst, Div Nephrol, Ctr Immun Inflammat & Regenerat Med, Charlottesville, VA USA
来源：
NEPHRON CLINICAL PRACTICE | 2014年 / 127卷 / 1-4期
基金：
美国国家卫生研究院;
关键词：
Aging; Kidney; Renal function; Regenerative capacity; MESENCHYMAL STEM-CELLS; ACUTE KIDNEY INJURY; PROGENITOR CELLS; SENESCENCE; REPAIR; AGE; TELOMERASE; MECHANISMS; ISCHEMIA; INSIGHTS;
D O I：
10.1159/000363708
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Along with the increase in aging of our population, the proportion of older patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) is on the rise as a result of the accumulation of comorbidities as well as biological processes associated with aging. Older patients with acute kidney injury (AKI) comprise an increasing proportion of patients with CKD/ESRD as well. In this review, we will discuss biological processes of aging that predispose patients to AKI and CKD. (C) 2014 S. Karger AG, Basel
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收藏
页码：15 / 20
页数：6
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