4′-α-C-branched N,O-nucleosides:: synthesis and biological properties

被引：13
|
作者：
Chiacchio, U
Genovese, F
Iannazzo, D
Piperno, A
Quadrelli, P
Antonino, C
Romeo, R
Valveri, V
Mastino, A
机构：
[1] Univ Messina, Dipartimento Farmacochim, I-98168 Messina, Italy
[2] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy
[3] Univ Pavia, Dipartimento Chim Organ, I-27100 Pavia, Italy
[4] Univ Messina, Dipartimento Sci Microbiol Genet & Mol, I-98100 Messina, Italy
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 14期
关键词：
modified nucleosides; 1,3-dipolar cycloaddition; antiviral activity; apoptotic activity; C-branched nucleosides;
D O I：
10.1016/j.bmc.2004.04.041
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis of 4'-alpha-C-branched N,O-nucleosides has been described, based on the 1,3-dipolar cycloaddition of nitrones with vinyl acetate followed by coupling with silylated nucleobases, The obtained compounds have been evaluated for their activity against HSV-1, HSV-2, HTLV-1. Cytotoxicity and apoptotic activity have been also investigated: compound 10c shows moderate apoptotic activity in Molt-3 cells. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3903 / 3909
页数：7
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