Deamination of 5′-substituted-2′,3′-isopropylidene adenosine derivatives catalyzed by adenosine deaminase (ADA, EC 3.5.4.4) and complementary enzymatic biotransformations catalyzed by adenylate deaminase (AMPDA, EC 3.5.4.6):: a viable route for the preparation of 5′-substituted inosine derivatives

被引：25

作者：

Ciuffreda, P ^{[1
]}

Loseto, A ^{[1
]}

Santaniello, E ^{[1
]}

机构：

[1] Univ Milan, LITA, Dipartimento Sci Preclin, I-20157 Milan, Italy

来源：

TETRAHEDRON | 2002年 / 58卷 / 29期

关键词：

biotransformations; adenosin deaminase; deamination;

D O I：

10.1016/S0040-4020(02)00575-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Adenosine deaminase (ADA) catalyzes the deamination of 2',3'-isopropylidene adenosine and the corresponding 5'-amino derivative in a 3% dimethylsulfoxide aqueous solution. Whereas ADA is unable to convert other 5'-substituted derivatives (acetate, acetamido, azide), the enzyme adenylate deaminase (AMPDA) accepts all the above compounds as substrates for their biotransformation to the corresponding 5'-substituted inosine derivatives. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：5767 / 5771

页数：5

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