Microbes, Microbiota, and Colon Cancer

被引：624

作者：

Sears, Cynthia L. ^{[1
,2
,3
,4
]}

Garrett, Wendy S. ^{[5
,6
,7
,8
,9
,10
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA

[4] Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA

[5] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

[6] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA

[7] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[8] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[9] Broad Inst Harvard, Cambridge, MA 02142 USA

[10] MIT, Cambridge, MA 02142 USA

来源：

CELL HOST & MICROBE | 2014年 / 15卷 / 03期

关键词：

HUMAN GUT MICROBIOME; ENTEROTOXIGENIC BACTEROIDES-FRAGILIS; STREPTOCOCCUS-GALLOLYTICUS INFECTION; BETA-GLUCURONIDASE INHIBITION; NF-KAPPA-B; COLORECTAL-CANCER; ESCHERICHIA-COLI; TUMOR MICROENVIRONMENT; URSODEOXYCHOLIC ACID; COMMENSAL BACTERIA;

D O I：

10.1016/j.chom.2014.02.007

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Colorectal cancer (CRC) presents a considerable disease burden worldwide. The human colon is also an anatomical location with the largest number of microbes. It is natural, therefore, to anticipate a role for microbes, particularly bacteria, in colorectal carcinogenesis. The increasing accessibility of microbial meta'omics is fueling a surge in our understanding of the role that microbes and the microbiota play in CRC. In this review, we will discuss recent insights into contributions of the microbiota to CRC and explore conceptual frameworks for evaluating the role of microbes in cancer causation. We also highlight new findings on candidate CRC-potentiating species and current knowledge gaps. Finally, we explore the roles of microbial metabolism as it relates to bile acids, xenobiotics, and diet in the etiology and therapeutics of CRC.

引用

页码：317 / 328

页数：12

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