Therapeutic HPV vaccines

被引：75
作者：
Hancock, Gemma [1 ,2 ]
Hellner, Karin [3 ]
Dorrell, Lucy [1 ,2 ,3 ]
机构：
[1] Univ Oxford, Nuffield Dept Med, NDM Res Bldg,Old Rd Campus, Oxford, England
[2] Oxford NIHR Biomed Res Ctr, NDM Res Bldg,Old Rd Campus, Oxford, England
[3] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Obstet & Gynaecol, Womens Ctr, Oxford, England
来源：
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY | 2018年 / 47卷
关键词：
High-risk human papillomavirus; HPV-Associated malignancies; Therapeutic vaccine; Viral vector; DNA vaccine; Bacterial vector; CERVICAL INTRAEPITHELIAL NEOPLASIA; REGULATORY T-CELLS; HUMAN-PAPILLOMAVIRUS TYPE-16; PLASMID DNA VACCINES; AGED; 16-26; YEARS; PARTICLE VACCINE; MVA E2; INTRAMUSCULAR INJECTION; SPONTANEOUS REGRESSION; ANTIGEN PRESENTATION;
D O I：
10.1016/j.bpobgyn.2017.09.008
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
High-risk human papillomavirus (HPV) infection is known to be a necessary factor for cervical and anogenital malignancies. Cervical cancers account for over a quarter of a million deaths annually. Despite the availability of prophylactic vaccines, HPV infections remain extremely common worldwide. Furthermore, these vaccines are ineffective at clearing pre-existing infections and associated preinvasive lesions. As cervical dysplasia can regress spontaneously, a therapeutic HPV vaccine that boosts host immunity could have a significant impact on the morbidity and mortality associated with HPV. Therapeutic vaccines differ from prophylactic vaccines in that they are aimed at generating cell mediated immunity rather than neutralising antibodies. This review will cover various therapeutic vaccine strategies in development for the treatment of HPV-associated lesions and cancers. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：59 / 72
页数：14
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