Regulation of Allergic Immune Responses by Microbial Metabolites

被引：14

作者：

Park, Hyun Jung ^{[1
]}

Lee, Sung Won ^{[1
]}

Hong, Seokmann ^{[1
]}

机构：

[1] Sejong Univ, Inst Anticanc Med Dev, Dept Integrat Biosci & Biotechnol, 209 Neungdong Ro, Seoul 05006, South Korea

来源：

IMMUNE NETWORK | 2018年 / 18卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Microbial metabolites; Dermatitis; atopic; Food allergy; Poly-gamma-glutamic acid; iNKT cells; ATOPIC-DERMATITIS; T-CELLS; INTERFERON-GAMMA; FOOD ALLERGY; GLUTAMIC ACID; ORAL TOLERANCE; AIRWAY INFLAMMATION; BACILLUS-SUBTILIS; LANGERHANS CELLS; DENDRITIC CELLS;

D O I：

10.4110/in.2018.18.e15

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Emerging evidence demonstrates that the microbiota plays an essential role in shaping the development and function of host immune responses. A variety of environmental stimuli, including foods and commensals, are recognized by the host through the epithelium, acting as a physical barrier. Two allergic diseases, atopic dermatitis and food allergy, are closely linked to the microbiota, because inflammatory responses occur on the epidermal border. The microbiota generates metabolites such as short-chain fatty acids and poly-gamma-glutamic acid (gamma PGA), which can modulate host immune responses. Here, we review how microbial metabolites can regulate allergic immune responses. Furthermore, we focus on the effect of gamma PGA on allergic T helper (Th) 2 responses and its therapeutic application.

引用

页数：16

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