Correlation between Hippo-YAP signaling pathway and liver cancer

被引：1

作者：

Ji, Y. B. ^{[1
,2
]}

Yu, W. J. ^{[1
,2
,3
]}

Xin, G. S. ^{[1
,2
]}

He, J. X. ^{[1
,2
]}

机构：

[1] Harbin Univ Commerce, Med Postdoctoral Workstn, Harbin 150076, Heilongjiang, Peoples R China

[2] Natl Minist Educ, Antitumor Nat Drug Engn Res Ctr, Harbin 150076, Heilongjiang, Peoples R China

[3] Harbin Univ Commerce, Coll Pharm, Harbin 150076, Heilongjiang, Peoples R China

来源：

2018 INTERNATIONAL CONFERENCE ON ZOOLOGY, BOTANY AND ECOLOGY (ICZBE 2018) | 2019年

关键词：

Hippo-YAP signaling pathway; YAP; liver cancer; YES-ASSOCIATED PROTEIN; SIZE;

D O I：

10.25236/iczbe.2018.004

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Hippo signaling pathway is a pathway that inhibits cell growth and controls organ size primarily by regulating cell proliferation and apoptosis. Cancer has long been considered by humans to be the "number one killer" and is known as an incurable disease. Among them, liver cancer is one of the malignant tumors that seriously threaten people's health. Therefore, it is particularly important to develop effective early diagnostic markers and therapeutic targets for liver cancer. This article reviews the composition and function of Hippo-YAP signaling pathway and its correlation between liver cancer, aiming at the early diagnosis of liver cancer, improving the specificity and targeting of liver cancer treatment, and reducing the damage to chemotherapy drugs to normal stem cells. The mechanism of drug resistance to liver cancer provides an effective basis and plays a role in assessing prognosis.

引用

页码：17 / 20

页数：4

共 17 条

[1] Arhgef7 promotes activation of the Hippo pathway core kinase Lats [J].