Macromolecular conjugate based particulates: Preparation, characterisation and evaluation of controlled release properties

被引：19

作者：

Zhang, Liyan ^{[1
,2
]}

Dudhani, Anitha ^{[3
]}

Lundin, Leif ^{[1
]}

Kosaraju, Shantha L. ^{[1
]}

机构：

[1] Food Sci Australia, CSIRO, Werribee, Vic 3030, Australia

[2] Prestige Foods Mfg, Braeside, Vic 3195, Australia

[3] Monash Inst Pharmaceut Sci, Dept Pharm Practice, Parkville, Vic 3052, Australia

来源：

EUROPEAN POLYMER JOURNAL | 2009年 / 45卷 / 07期

关键词：

Chitosan; Whey protein isolate; Catechin; Controlled release; CHITOSAN MICROSPHERES; BETA-LACTOGLOBULIN; PROTEIN; MICROENCAPSULATION; NANOPARTICLES; POLYPHENOLS;

D O I：

10.1016/j.eurpolymj.2009.04.019

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A new particulate delivery matrix based on macromolecular conjugate, chitosan-whey protein isolate ([Ch-WPI]) was found to exhibit controlled release properties. Fourier-Transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) demonstrated the formation of the conjugate. Particle formation of the conjugate was carried out by the ionic crosslinking technique using sodium tripolyphospate (STP). Catechin entrapped particles were prepared by varying the weight ratios of STP to conjugate [Ch-WPI]. Both the placebo and catechin-entrapped particles were found to be positively charged below pH 7.2, indicating their stability to aggregation and their suitability for bio-adhesion in the gastrointestinal tract (GIT). The entrapment efficiencies of the particles ranged between 29% and 42% for particles prepared using different weight ratios of the conjugate to STP. There was 34-56% of catechin release in simulated GIT conditions depending on the entrapment efficiencies and the degree of crosslinking of the particles. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1960 / 1969

页数：10

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