Moringa oleifera Lam and its Therapeutic Effects in Immune Disorders

被引:42
作者
Xiao, Xiao [1 ,2 ,3 ,4 ]
Wang, Jue [5 ]
Meng, Chen [4 ]
Liang, Weibo [4 ]
Wang, Tao [3 ]
Zhou, Bin [3 ]
Wang, Yanyun [3 ]
Luo, Xiaolei [3 ]
Gao, Linbo [3 ]
Zhang, Lin [3 ,4 ]
机构
[1] Sichuan Univ, West China Univ Hosp 2, Dept Obstet & Gynecol, Chengdu, Peoples R China
[2] Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Child, Minist Educ, Chengdu, Peoples R China
[3] Sichuan Univ, Lab Mol Translat Med, Ctr Translat Med,Minist Educ,West China Univ Hosp, Key Lab Birth Defects & Related Dis Women & Child, Chengdu, Peoples R China
[4] Sichuan Univ, West China Sch Basic Med Sci & Forens Med, Dept Forens Genet, Chengdu, Peoples R China
[5] Chengdu Second Peoples Hosp, Dept Geriatr, Chengdu, Peoples R China
基金
中国国家自然科学基金;
关键词
Moringa oleifera; infection; chronic inflammation; physicochemical irritation; autoimmune disorders; GUINEA-PIG MODEL; LEAF EXTRACT; ANTIOXIDANT ACTIVITY; AIRWAY INFLAMMATION; HEAVY-METALS; SEEDS; FRACTION; BIOSORPTION; TOXICITY; REMOVAL;
D O I
10.3389/fphar.2020.566783
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Moringa oleifera Lam., a plant native to tropical forests of India, is characterized by its versatile application as a food additive and supplement therapy. Accumulating evidence shows that Moringa plays a critical role in immune-related diseases. In this review, we cover the history, constituents, edibility, and general medicinal value of Moringa. The effects of Moringa in treating immune disorders are discussed in detail. Moringa can not only eliminate pathogens, including bacteria, fungi, viruses, and parasites, but also inhibit chronic inflammation, such as asthma, ulcerative colitis, and metabolic diseases. Additionally, Moringa can attenuate physical and chemical irritation-induced immune disorders, such as metal intoxication, drug side effects, or even the adverse effect of food additives. Autoimmune diseases, like rheumatoid arthritis, atopic dermatitis, and multiple sclerosis, can also be inhibited by Moringa. Collectively, Moringa, with its multiple immune regulatory bioactivities and few side effects, has a marked potential to treat immune disorders.
引用
收藏
页数:9
相关论文
共 78 条
[1]   Palliative effects of Moringa olifera ethanolic extract on hemato-immunologic impacts of melamine in rats [J].
Abd-Elhakim, Yasmina M. ;
El Bohi, Khlood M. ;
Hassan, Sahar Khalifa ;
El Sayed, Shorouk ;
Abd-Elmotal, Sabry M. .
FOOD AND CHEMICAL TOXICOLOGY, 2018, 114 :1-10
[2]  
Adedapo Adeolu Alex, 2015, Journal of Basic and Clinical Physiology and Pharmacology, V26, P491, DOI 10.1515/jbcpp-2014-0105
[3]  
Adeyemi OS, 2017, J BIOMED RES, V31, P350, DOI 10.7555/JBR.31.20160051
[4]   Ameliorative effect of naringin in acetaminophen-induced hepatic and renal toxicity in laboratory rats: role of FXR and KIM-1 [J].
Adil, Mohammad ;
Kandhare, Amit D. ;
Ghosh, Pinaki ;
Venkata, Shivakumar ;
Raygude, Kiran S. ;
Bodhankar, Subhash L. .
RENAL FAILURE, 2016, 38 (06) :1007-1020
[5]   ANTI-ULCEROGENIC EVALUATION OF THE METHANOLIC EXTRACTS OF SOME INDIGENOUS MEDICINAL-PLANTS OF PAKISTAN IN ASPIRIN-ULCERATED RATS [J].
AKHTAR, AH ;
AHMAD, KU .
JOURNAL OF ETHNOPHARMACOLOGY, 1995, 46 (01) :1-6
[6]   Processing of Moringa leaves as natural source of nutrients by optimization of drying and grinding mechanism [J].
Ali, M. A. ;
Yusof, Y. A. ;
Chin, N. L. ;
Ibrahim, M. N. .
JOURNAL OF FOOD PROCESS ENGINEERING, 2017, 40 (06)
[7]   Moringa Leaves Prevent Hepatic Lipid Accumulation and Inflammation in Guinea Pigs by Reducing the Expression of Genes Involved in Lipid Metabolism [J].
Almatrafi, Manal Mused ;
Vergara-Jimenez, Marcela ;
Murillo, Ana Gabriela ;
Norris, Gregory H. ;
Blesso, Christopher N. ;
Fernandez, Maria Luz .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (07)
[8]  
[Anonymous], 2011, BRIT J PHARMACOL
[9]   Moringa oleifera:: A food plant with multiple medicinal uses [J].
Anwar, Farooq ;
Latif, Sajid ;
Ashraf, Muhammad ;
Gilani, Anwarul Hassan .
PHYTOTHERAPY RESEARCH, 2007, 21 (01) :17-25
[10]   Moringa oleifera Leaf Extracts as Multifunctional Ingredients for "Natural and Organic" Sunscreens and Photoprotective Preparations [J].
Baldisserotto, Anna ;
Buso, Piergiacomo ;
Radice, Matteo ;
Dissette, Valeria ;
Lampronti, Ilaria ;
Gambari, Roberto ;
Manfredini, Stefano ;
Vertuani, Silvia .
MOLECULES, 2018, 23 (03)