Vibralactone:: A lipase inhibitor with an unusual fused β-lactone produced by cultures of the basidiomycete Boreostereum vibrans

被引：163

作者：

Liu, Dong-Ze

Wang, Fei

Liao, Tou-Gen

Tang, Jian-Guo

Steglich, Wolfgang

Zhu, Hua-Jie

Liu, Ji-Kai ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

[3] Univ Munich, Dept Chem, D-81377 Munich, Germany

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 25期

关键词：

D O I：

10.1021/ol062307u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The structure and absolute configuration of vibralactone (1) from the cultures of the Basidiomycete Boreostereum vibrans were established by spectroscopic methods and computational methods. Vibralactone, an unusual fused beta-lactone-type metabolite, was found to inhibit pancreatic lipase with an IC50 of 0.4 mu g/mL.

引用

页码：5749 / 5752

页数：4

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