Vibralactone:: A lipase inhibitor with an unusual fused β-lactone produced by cultures of the basidiomycete Boreostereum vibrans

被引：161
作者：
Liu, Dong-Ze
Wang, Fei
Liao, Tou-Gen
Tang, Jian-Guo
Steglich, Wolfgang
Zhu, Hua-Jie
Liu, Ji-Kai [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
[3] Univ Munich, Dept Chem, D-81377 Munich, Germany
来源：
ORGANIC LETTERS | 2006年 / 8卷 / 25期
关键词：
D O I：
10.1021/ol062307u
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The structure and absolute configuration of vibralactone (1) from the cultures of the Basidiomycete Boreostereum vibrans were established by spectroscopic methods and computational methods. Vibralactone, an unusual fused beta-lactone-type metabolite, was found to inhibit pancreatic lipase with an IC50 of 0.4 mu g/mL.
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页码：5749 / 5752
页数：4
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