Sex and gender influence symptom manifestation and survival in multiple system atrophy

被引：21

作者：

Coon, Elizabeth A. ^{[1
]}

Nelson, Renee M. ^{[1
]}

Sletten, David M. ^{[1
]}

Suarez, Mariana D. ^{[1
]}

Ahlskog, J. Eric ^{[1
]}

Benarroch, Eduardo E. ^{[1
]}

Sandroni, Paola ^{[1
]}

Mandrekar, Jay N. ^{[2
]}

Low, Phillip A. ^{[1
]}

Singer, Wolfgang ^{[1
]}

机构：

[1] Mayo Clin, Dept Neurol, 200 First St SW, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Biomed Stat & Informat, Rochester, MN USA

来源：

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | 2019年 / 219卷

关键词：

Multiple system atrophy; Sex; Gender; Parkinsonism; Ataxia; Autonomic; NATURAL-HISTORY; CLINICAL-FEATURES; DYSFUNCTION; PROGNOSIS;

D O I：

10.1016/j.autneu.2019.04.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To evaluate the influence of sex and gender on clinical characteristics and survival in multiple system atrophy (MSA), we reviewed MSA patients with autonomic testing 1998-2012. Of 685 patients, 52% were male. Median survival overall was 7.3 years for males, 7.6 years for females. Survival from diagnosis was 2.9 years in males, 3.8 years in females. Females were more likely to initially manifest motor symptoms. Males were more likely to have orthostatic intolerance and early catheterization. In conclusion, our data show longer survival from diagnosis in-females and slight-overall survival benefit which - may be related to motor manifestations.

引用

页码：49 / 52

页数：4

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