Catalytic use of chiral phosphine ligands in asymmetric Pauson-Khand reactions

被引：82

作者：

Hiroi, K ^{[1
]}

Watanabe, T ^{[1
]}

Kawagishi, R ^{[1
]}

Abe, I ^{[1
]}

机构：

[1] Tohoku Pharmaceut Univ, Dept Synthet Organ Chem, Aoba Ku, Sendai, Miyagi 9818558, Japan

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0957-4166(99)00570-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Catalytic asymmetric Pauson-Khand reactions with chiral bidentate phosphines as ligands have been successfully accomplished. The catalytic use of (S)-BINAP as a ligand was demonstrated to be the most effective in the cobalt-catalyzed reactions of 1,6-enynes, providing a facile entry to optically active 2-cyclopentenone derivatives with high enantioselectivity. A plausible mechanism for the asymmetric induction is proposed on the basis of the stereochemical outcome obtained. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：797 / 808

页数：12

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