Synthesis and Anti-H5N1 Activity of Substituted Pyridine Glycosides and (Oxadiazolyl)oxymethylpyridine Acyclic C-Nucleoside Analogues

被引：13

作者：

Soliman, H. A. ^{[1
]}

Kotb, E. R. ^{[1
]}

El-Bayaa, M. N. ^{[1
]}

Kutkat, O. M. ^{[2
]}

Abdel-Magied, F. M. E. ^{[1
]}

机构：

[1] Natl Res Ctr, Photochem Dept, Giza 12622, Egypt

[2] Natl Res Ctr, Environm Res Div, Cairo 12622, Egypt

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2018年 / 88卷 / 04期

关键词：

pyridine; sugar hydrazones; oxadiazole; acyclic nucleosides; H5N1; virus; 1,3,4-OXADIAZOLE DERIVATIVES; BIOLOGICAL EVALUATION; ANTITUMOR ACTIVITIES; ANTIVIRAL EVALUATION; ANTICANCER ACTIVITY; VIRUS ACTIVITY; AGENTS; INHIBITORS; THERAPY; MOIETY;

D O I：

10.1134/S1070363218040291

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New aryl- and heteroaryl-substituted pyridinyl sugar hydrazones and their derivatives, 1,3,4-oxadiazole acyclic C-nucleosides, were synthesized. Novel O-glycoside derivatives of the substituted pyridines were prepared. The antiviral activity against avian influenza H5N1 virus was studied and compounds 5a, 9a, and 14 demonstrated high inhibition activity.

引用

页码：815 / 824

页数：10

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