Synthesis and Anti-H5N1 Activity of Substituted Pyridine Glycosides and (Oxadiazolyl)oxymethylpyridine Acyclic C-Nucleoside Analogues

被引：13
|
作者：
Soliman, H. A. [1 ]
Kotb, E. R. [1 ]
El-Bayaa, M. N. [1 ]
Kutkat, O. M. [2 ]
Abdel-Magied, F. M. E. [1 ]
机构：
[1] Natl Res Ctr, Photochem Dept, Giza 12622, Egypt
[2] Natl Res Ctr, Environm Res Div, Cairo 12622, Egypt
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2018年 / 88卷 / 04期
关键词：
pyridine; sugar hydrazones; oxadiazole; acyclic nucleosides; H5N1; virus; 1,3,4-OXADIAZOLE DERIVATIVES; BIOLOGICAL EVALUATION; ANTITUMOR ACTIVITIES; ANTIVIRAL EVALUATION; ANTICANCER ACTIVITY; VIRUS ACTIVITY; AGENTS; INHIBITORS; THERAPY; MOIETY;
D O I：
10.1134/S1070363218040291
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
New aryl- and heteroaryl-substituted pyridinyl sugar hydrazones and their derivatives, 1,3,4-oxadiazole acyclic C-nucleosides, were synthesized. Novel O-glycoside derivatives of the substituted pyridines were prepared. The antiviral activity against avian influenza H5N1 virus was studied and compounds 5a, 9a, and 14 demonstrated high inhibition activity.
引用
收藏
页码：815 / 824
页数：10
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