p12CDK2-AP1 is associated with tumor progression and a poor prognosis in esophageal squamous cell carcinoma

被引：23

作者：

Hiyoshi, Yukiharu ^{[1
]}

Watanabe, Masayuki ^{[1
]}

Hirashima, Koutaro ^{[1
,2
]}

Karashima, Ryuichi ^{[1
]}

Sato, Nobutaka ^{[1
]}

Imamura, Yu ^{[1
]}

Nagai, Youhei ^{[1
]}

Yoshida, Naoya ^{[1
]}

Toyama, Elichiro ^{[1
]}

Hayashi, Naoko ^{[1
]}

Baba, Hideo ^{[1
]}

机构：

[1] Kumamoto Univ Hosp, Dept Surg Gastroenterol, Grad Sch Med Sci, Kumamoto 8608556, Japan

[2] Kumamoto Univ Hosp, Dept Surg Pathol, Kumamoto 8608556, Japan

来源：

ONCOLOGY REPORTS | 2009年 / 22卷 / 01期

关键词：

p12; CDK2AP1; esophageal cancer; LYMPH-NODE METASTASIS; ENDOSCOPIC MUCOSAL RESECTION; HUMAN COLORECTAL-CANCER; THORACIC ESOPHAGUS; SUPPRESSOR GENE; EXPRESSION; P12(DOC-1); DOC-1; FEATURES; P53;

D O I：

10.3892/or_00000403

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

p12 CDK2-associating protein 1 (p12(CDK2-AP1)) is a growth suppressor that negatively regulates cyclin-dependent kinase 2 (CDK2) activities. In addition, p12(CDK2-AP1) has also been shown to interfere in DNA replication. A reduction of p12(CDK2-AP1) expression is known to be a negative prognostic , indicator in patients with oral squamous cell carcinoma. To elucidate the role of p12(CDK2-AP1) expression in esophageal squamous cell carcinoma (ESCC), we immunohistochemically examined the expression of p12(CDK2-AP1) protein in 120 resected ESCC specimens and determined its association with the clinicopathological characteristics and prognosis. Of the 120 ESCCs, 79 (65.8%) showed positive staining (>= 25% of cancer cells showing p12(CDK2-AP1) expression), while 41 (34.2%) lacked the staining (<25% of cancer cells showing p12(CDK2-AP1) expression). Negative staining for p12(CDK2-AP1) was found to be significantly associated with advanced lesions [depth of tumor (P=0.001), lymph node metastasis (P<0.001), pathological stage (P<0.0001) and venous invasion (P<0.0001)], and a poor prognosis (disease-free survival and overall survival: log-rank P<0.05). The rate of lymph node metastasis in patients with p12(CDK2-AP1) negative-T1 ESCC was significantly higher than that in patients with p12(CDK2-AP1) positive one (P<0.05). These results suggest the down-regulation of p12(CDK2-AP1) to be related to tumor aggressiveness and a poor prognosis in patients with ESCC.

引用

页码：35 / 39

页数：5

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