Assaying antacids for neutralizing capacity with different indicators

被引：0

作者：

Mir, S. A. ^{[1
]}

Ahmad, Azad ^{[1
]}

机构：

[1] Shere Kashmir Univ Agr Sci & Technol, Fac Vet Sci & Anim Husb, Div Vet Pharmacol & Toxicol, Srinagar 190001, Jammu & Kashmir, India

来源：

ASIAN JOURNAL OF CHEMISTRY | 2006年 / 18卷 / 04期

关键词：

neutralizing capacity; antacids; copper sulfate; indicators;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Antacids have been assayed titrimetrically for their neutralizing capacity using copper sulfate, methyl orange and methyl red as indicators of equivalence points. End-point with copper sulfate is marked with the appearance of a stable bluish-white turbidity. Estimated values (mL 1 N acid consumed per 100 mg antacid base) with copper sulfate did not differ from those obtained with methyl orange (P > 0.1). The values obtained with methyl red were significantly lower than those obtained with either copper sulfate or with methyl orange for those preparations containing aluminum as common cationic species (P < 0.05) and for others were not significantly different (P > 0.1). Investigations reveal that choice of indicators affects estimated values and copper sulfate is a valuable substitute to methyl orange for assaying antacids for neutralizing capacity. Copper sulfate offers obvious advantages, provides stable end-point and is suitable for measuring titratable acidity of coloured solutions.

引用

页码：2742 / 2746

页数：5