Antibody-Mediated Immune Control of a Retrovirus Does Not Require the Microbiota

被引：6
作者：
Wilks, Jessica [1 ]
Beilinson, Helen [1 ]
Theriault, Betty [2 ]
Chervonsky, Alexander [3 ]
Golovkina, Tatyana [1 ]
机构：
[1] Univ Chicago, Dept Microbiol, Chicago, IL 60637 USA
[2] Univ Chicago, Dept Surg, Chicago, IL 60637 USA
[3] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA
来源：
JOURNAL OF VIROLOGY | 2014年 / 88卷 / 11期
关键词：
I/LNJ MICE; INTESTINAL MICROBIOTA; COMMENSAL BACTERIA; FRIEND RETROVIRUS; VIRUS-INFECTION; GERM-FREE; RESISTANCE; RESPONSES; TRANSMISSION; REPLICATION;
D O I：
10.1128/JVI.00251-14
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Commensal microbes are often required to control viral infection by facilitating host immune defenses. However, we found that this does not hold true for retroviral infection. We report that retrovirus-resistant mice control the pathogen with virus-neutralizing antibodies independently of commensal microbiota. This is in contrast to orthomyxoviruses and arenaviruses, where resistance is ablated in animals depleted of microbiota. Clearly, when it comes to antiviral immunity, the role of the microbiota cannot be generalized.
引用
收藏
页码：6524 / 6527
页数：4
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