Palladium-Catalyzed Distal C-H Selenylation of 2-Aryl Acetamides with Diselenides and Selenyl Chlorides

被引：19

作者：

He, Meicui ^{[1
]}

Gu, Linghui ^{[1
]}

Tan, Yuqiang ^{[1
]}

Wang, Yang ^{[1
]}

Wang, Yuchi ^{[1
]}

Zhang, Chunran ^{[1
]}

Ma, Wenbo ^{[1
]}

机构：

[1] Chengdu Univ, Sichuan Ind Inst Antibiot, Antibiot Res & Reevaluat Key Lab Sichuan Prov, Chengdu 610052, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2020年 / 362卷 / 24期

关键词：

Palladium catalyst; C-H selenylation; Removable directing group; 2-Aryl acetamides; Single-electron transfer; UNACTIVATED C(SP(3))-H BONDS; DIRECT THIOLATION; DIRECT SELENATION; CHALCOGENATION; ARENES; FUNCTIONALIZATION; SULFENYLATION; DERIVATIVES; DISULFIDES; DRUGS;

D O I：

10.1002/adsc.202000948

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A convenient and effective method of palladium-catalyzed C-H selenylation of the 2-aryl acetamides assisted with removable 8-aminoquinoline with readily available diselenides and selenyl chlorides has been developed. This selenylation reaction is scalable and tolerates a wide range of functional groups, providing a straightforward way of the preparing unsymmetrical diaryl selenides and dibenzoselene-pinone. Preliminary mechanistic studies indicated that a single-electron transfer type mechanism and facile C-H metalation are operative.

引用

页码：5708 / 5715

页数：8

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