NEDD4: A Promising Target for Cancer Therapy

被引：60
|
作者：
Ye, Xiantao [1 ,2 ]
Wang, Lixia [1 ,2 ]
Shang, Bingxue [1 ,2 ]
Wang, Zhiwei [1 ,2 ]
Wei, Wenyi [3 ]
机构：
[1] Soochow Univ, Affiliated Hosp 1, Jiangsu Inst Hematol, Cyrus Tang Hematol Ctr, Suzhou 215123, Jiangsu, Peoples R China
[2] Soochow Univ, Affiliated Hosp 1, Jiangsu Inst Hematol, Collaborat Innovat Ctr Hematol, Suzhou 215123, Jiangsu, Peoples R China
[3] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA
来源：
CURRENT CANCER DRUG TARGETS | 2014年 / 14卷 / 06期
关键词：
Cancer; E3; ligase; NEDD4; oncogene; target; therapy; ubiquitination; UBIQUITIN LIGASE NEDD4-1; TUMOR-SUPPRESSOR; E3; LIGASE; DEPENDENT UBIQUITINATION; NEGATIVE REGULATOR; HECT FAMILY; GROWTH; PROTEIN; ENDOCYTOSIS; ACTIVATION;
D O I：
10.2174/1568009614666140725092430
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The Neuronally expressed developmentally downregulated 4 (NEDD4), functioning largely as an E3 ubiquitin ligase, has been demonstrated to play a critical role in the development and progression of human cancers. In this review, to understand the regulatory mechanism(s) of NEDD4 as well as the signaling pathways controlled by NEDD4, we briefly describe the NEDD4 upstream regulators and its downstream ubiquitin substrates. Moreover, we further discuss its oncogenic roles in human malignancies. Therefore, targeting NEDD4 could be a potential therapeutic strategy for treatment of human cancers.
引用
收藏
页码：549 / 556
页数：8
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