State of the Science in Cervical Cancer: Where We Are Today and Where We Need to Go

被引：43

作者：

Dizon, Don S. ^{[1
,2
]}

Mackay, Helen J. ^{[3
,4
]}

Thomas, Gillian M. ^{[5
,6
]}

Werner, Theresa L. ^{[7
]}

Kohn, Elise C. ^{[8
]}

Hess, Dina ^{[9
]}

Rose, Peter G. ^{[10
]}

Covens, Allan L. ^{[11
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Canc, Gillette Ctr Gynecol Oncol, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA USA

[3] Princess Margaret Hosp, Div Med Oncol & Hematol, Toronto, ON M4X 1K9, Canada

[4] Univ Toronto, Dept Med, Toronto, ON, Canada

[5] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Radiat Oncol, Toronto, ON, Canada

[6] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Obstet & Gynecol, Toronto, ON, Canada

[7] Univ Utah, Sch Med, Dept Med, Div Oncol, Salt Lake City, UT USA

[8] NCI, Clin Invest Branch, Canc Therapy Evaluat Program, Div Canc Treatment & Diag, Bethesda, MD 20892 USA

[9] NCI, Gynecol Oncol Steering Comm, EMMES Corp, Rockville, MD USA

[10] Cleveland Clin Fdn, Dept Obstet & Gynecol, Div Gynecol Oncol, Cleveland, OH 44195 USA

[11] Univ Toronto, Sunnybrook Hlth Sci Ctr, Div Gynecol Oncol, Dept Obstet & Gynecol, Toronto, ON, Canada

来源：

CANCER | 2014年 / 120卷 / 15期

关键词：

cervical cancer; clinical trials; human papillomavirus; immunotherapy; anti-angiogenesis; screening; prevention; PELVIC RADIATION-THERAPY; PHASE-III TRIAL; PLUS CISPLATIN; RIBONUCLEOTIDE REDUCTASE; CONCURRENT CHEMOTHERAPY; ADJUVANT GEMCITABINE; IMMUNE-RESPONSES; ONCOLOGY-GROUP; IVA CARCINOMA; STAGE IIB;

D O I：

10.1002/cncr.28722

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Invasive cervical cancer remains an important global cause of death, despite the declining prevalence within the United States. Definitive therapies, including surgical resection of early-stage disease and chemoradiation for locally advanced disease, can be curative. For women who experience local or distant recurrences, the prognosis remains poor and better treatments are required. On July 18, 2013, The Gynecologic Oncology Group sponsored a State of the Science in Cervical Cancer Symposium with experts, researchers, clinicians, and interested stakeholders. This article summarize the progress that has been made, questions that require further investigation, and contemporary genomic findings and innovative treatments that may help inform the next generation of clinical trials for patients with cervical cancer. (C) 2014 American Cancer Society.

引用

页码：2282 / 2288

页数：7

共 37 条

[31] Immune responses against human papillomavirus (HPV) infection and evasion of host defense in cervical cancer [J].

Sasagawa, Toshiyuki ;

Takagi, Hiroaki ;

Makinoda, Satoru .

JOURNAL OF INFECTION AND CHEMOTHERAPY, 2012, 18 (06) :807-815

[32]

Shastri SS, 2013, J CLIN ONCOL S, V31

[33] Inhibition of Poly(ADP-Ribose) Polymerase Enhances Radiochemosensitivity in Cancers Proficient in DNA Double-Strand Break Repair [J].

Shunkwiler, Lauren ;

Ferris, Gina ;

Kunos, Charles .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 14 (02) :3773-3785

[34] Cancer statistics, 2013 [J].

Siegel, Rebecca ;

Naishadham, Deepa ;

Jemal, Ahmedin .

CA-A CANCER JOURNAL FOR CLINICIANS, 2013, 63 (01) :11-30

[35] Safety, Activity, and Immune Correlates of Anti-PD-1 Antibody in Cancer [J].

Topalian, Suzanne L. ;

Hodi, F. Stephen ;

Brahmer, Julie R. ;

Gettinger, Scott N. ;

Smith, David C. ;

McDermott, David F. ;

Powderly, John D. ;

Carvajal, Richard D. ;

Sosman, Jeffrey A. ;

Atkins, Michael B. ;

Leming, Philip D. ;

Spigel, David R. ;

Antonia, Scott J. ;

Horn, Leora ;

Drake, Charles G. ;

Pardoll, Drew M. ;

Chen, Lieping ;

Sharfman, William H. ;

Anders, Robert A. ;

Taube, Janis M. ;

McMiller, Tracee L. ;

Xu, Haiying ;

Korman, Alan J. ;

Jure-Kunkel, Maria ;

Agrawal, Shruti ;

McDonald, Daniel ;

Kollia, Georgia D. ;

Gupta, Ashok ;

Wigginton, Jon M. ;

Sznol, Mario .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (26) :2443-2454

[36] Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: A Gynecologic Oncology Group and Southwest Oncology Group Study [J].

Whitney, CW ;

Sause, W ;

Bundy, BN ;

Malfetano, JH ;

Hannigan, EV ;

Fowler, WC ;

Clarke-Pearson, DL ;

Liao, SY .

JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (05) :1339-1348

[37] Oncogenic Mutations in Cervical Cancer Genomic Differences Between Adenocarcinomas and Squamous Cell Carcinomas of the Cervix [J].

Wright, Alexi A. ;

Howitt, Brooke E. ;

Myers, Andrea P. ;

Dahlberg, Suzanne E. ;

Palescandolo, Emanuele ;

Van Hummelen, Paul ;

MacConaill, Laura E. ;

Shoni, Melina ;

Wagle, Nikhil ;

Jones, Robert T. ;

Quick, Charles M. ;

Laury, Anna ;

Katz, Ingrid T. ;

Hahn, William C. ;

Matulonis, Ursula A. ;

Hirsch, Michelle S. .

CANCER, 2013, 119 (21) :3776-3783

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