Characterization of ester- or thioamide-functionalized single-walled carbon nanotube-azithromycin conjugates

被引：14

作者：

Darabi, Hossein Reza ^{[1
]}

Roozkhosh, Atefeh ^{[1
]}

Tehrani, Mohammad Jafar ^{[1
]}

Aghapoor, Kioumars ^{[1
]}

Sayahi, Hani ^{[1
]}

Balavar, Yadollah ^{[1
]}

Mohsenzadeh, Farshid ^{[1
]}

机构：

[1] Chem & Chem Engn Res Ctr Iran, Nano & Organ Synth Lab, Tehran 1496813151, Iran

来源：

APPLIED SURFACE SCIENCE | 2014年 / 288卷

基金：

美国国家科学基金会;

关键词：

Functionalized carbon nanotubes; Azithromycin; Cleavable bonds; Drug release; In vitro therapy; WILLGERODT-KINDLER REACTION; DRUG-DELIVERY; PLASMID DNA; CELLS; TRANSPORTERS; CHEMOSELECTIVITY; TRANSLOCATION; MEMBRANES; PEPTIDES; PROTOCOL;

D O I：

10.1016/j.apsusc.2013.09.159

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Functionalization of single-walled carbon nanotubes (SWCNTs) with nitrile groups, followed by further reactions allowed direct attachment of azithromycin and its N-demethyl derivative to the side-walls of SWCNTs for the first time. With these approaches, the cleavable ester or thioamide bonds are formed to connect azithromycin to SWCNTs resulting in azithromycin-SWCNT conjugates. These cleavable bonds are able to control molecular release from nanotube surfaces which are generally applicable to a variety of hybrid materials based on SWCNTs. A non-covalent azithromycin-SWCNT has also been compared with azithromycin-SWCNTs conjugates. Thermogravimetric analysis (TGA), Fourier-transformed infrared (FTIR), UV-vis, and Raman spectroscopies give hints on the characterization of azithromycin-SWCNT. Both drug release and antimicrobial activity of azithromycin-SWCNT conjugates were also tested. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：122 / 129

页数：8

共 51 条

[1] The different, but interesting behaviors of benzyl systems in the Willgerodt-Kindler reaction under solvent-free conditions [J].

Aghapoor, K ;

Darabi, HR ;

Tabar-Heydar, K .

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2002, 177 (05) :1183-1187

[2]

Aghapoor K., 2002, SULFUR LETT, V25, P259, DOI DOI 10.1080/02786110215846

[3] The Willgerodt-Kindler reaction in water:: High chemoselectivity of benzaldehydes over acetophenones [J].

Aghapoor, Kioumars ;

Mohsenzadeh, Farshid ;

Khanalizadeh, Golriz ;

Darabi, Hossein R. .

MONATSHEFTE FUR CHEMIE, 2007, 138 (01) :61-65

[4]

[Anonymous], NANO LETT

[5] Cationic carbon nanotubes bind to CpG oligodeoxynucleotides and enhance their immunostimulatory properties [J].

Bianco, A ;

Hoebeke, J ;

Godefroy, S ;

Chaloin, O ;

Pantarotto, D ;

Briand, JP ;

Muller, S ;

Prato, M ;

Partidos, CD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (01) :58-59

[6] Biomedical applications of functionalised carbon nanotubes [J].

Bianco, A ;

Kostarelos, K ;

Partidos, CD ;

Prato, M .

CHEMICAL COMMUNICATIONS, 2005, (05) :571-577

[7]

Bianco Alberto, 2004, Expert Opin Drug Deliv, V1, P57, DOI 10.1517/17425247.1.1.57

[8] Making carbon nanotubes biocompatible and biodegradable [J].

Bianco, Alberto ;

Kostarelos, Kostas ;

Prato, Maurizio .

CHEMICAL COMMUNICATIONS, 2011, 47 (37) :10182-10188

[9] The potential environmental impact of engineered nanomaterials [J].

Colvin, VL .

NATURE BIOTECHNOLOGY, 2003, 21 (10) :1166-1170

[10] A review of DNA functionalized/grafted carbon nanotubes and their characterization [J].

Daniel, Sobhi ;

Rao, Talasila Prasada ;

Rao, Kota Sreenivasa ;

Rani, Sikhakolli Usha ;

Naidu, G. R. K. ;

Lee, Hea-Yeon ;

Kawai, Tomoji .

SENSORS AND ACTUATORS B-CHEMICAL, 2007, 122 (02) :672-682

← 1 2 3 4 5 6 →