Impact of Allele-Level HLA Mismatch on Outcomes in Recipients of Double Umbilical Cord Blood Transplantation

被引：35

作者：

Brunstein, Claudio G. ^{[1
]}

Petersdorf, Effie W. ^{[2
]}

Defor, Todd E. ^{[1
]}

Noreen, Harriet ^{[3
]}

Maurer, David ^{[3
]}

MacMillan, Margaret L. ^{[1
]}

Ustun, Celalettin ^{[1
]}

Verneris, Michael R. ^{[1
]}

Miller, Jeffrey S. ^{[1
]}

Blazar, Bruce R. ^{[1
]}

McGlave, Philip B. ^{[1
]}

Weisdorf, Daniel J. ^{[1
]}

Wagner, John E. ^{[1
]}

机构：

[1] Univ Minnesota, Blood & Marrow Transplant Program, Minneapolis, MN USA

[2] Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA

[3] Univ Minnesota, Immunol Lab, Minneapolis, MN USA

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2016年 / 22卷 / 03期

关键词：

Alternative donor transplant; Umbilical cord blood; Histocompatibility; DONOR MARROW TRANSPLANTATION; STEM-CELL TRANSPLANTATION; HEMATOLOGIC MALIGNANCIES; ACUTE-LEUKEMIA; UNIT; ADULTS; CONTRIBUTES; CONSENSUS; REGISTRY; DISEASE;

D O I：

10.1016/j.bbmt.2015.09.025

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The impact of allele-level HLA mismatch is uncertain in recipients of double umbilical cord blood (UCB) transplantation. We report a single-center retrospective study of the clinical effect of using allele-level HLA mismatch HLA-A, -B, -C, -DRB1, and -DQB1 of the 2 UCB units. We studied 342 patients with hematologic malignancy. Donor recipient pairs were grouped according to the number of matched HLA alleles, with 32 matched at 9-10/10, 202 at 6-8/10, and 108 at 2-5/10 alleles. The incidence of hematopoietic recovery, acute and chronic graft-versus-host disease, and nonrelapse mortality and treatment failure was similar between groups. In an exploratory analysis of 174 patients with acute leukemia, after adjusting for length of first remission and cytogenetic risk group, a 2-5/10 HLA match was associated with lower risk of relapse and treatment failure. These data indicate that a high degree of allele-level HLA mismatch does not adversely affect transplant outcomes and may be associated with reduced relapse risk in patients with acute leukemia. (C) 2016 American Society for Blood and Marrow Transplantation.

引用

页码：487 / 492

页数：6

共 27 条

[1]

ATKINSON K, 1989, BONE MARROW TRANSPL, V4, P247

[2] Different effects of HLA disparity on transplant outcomes after single-unit cord blood transplantation between pediatric and adult patients with leukemia [J].

Atsuta, Yoshiko ;

Kanda, Junya ;

Takanashi, Minoko ;

Morishima, Yasuo ;

Taniguchi, Shuichi ;

Takahashi, Satoshi ;

Ogawa, Hiroyasu ;

Ohashi, Kazuteru ;

Ohno, Yuju ;

Onishi, Yasushi ;

Aotsuka, Nobuyuki ;

Nagamura-Inoue, Tokiko ;

Kato, Koji ;

Kanda, Yoshinobu .

HAEMATOLOGICA, 2013, 98 (05) :814-822

[3] Influence of infused cell dose and HLA match on engraftment after double-unit cord blood allografts [J].

Avery, Sharon ;

Shi, Weiji ;

Lubin, Marissa ;

Gonzales, Anne Marie ;

Heller, Glenn ;

Castro-Malaspina, Hugo ;

Giralt, Sergio ;

Kernan, Nancy A. ;

Scaradavou, Andromachi ;

Barker, Juliet N. .

BLOOD, 2011, 117 (12) :3277-3285

[4] Combined effect of total nucleated cell dose and HLA match on transplantation outcome in 1061 cord blood recipients with hematologic malignancies [J].

Barker, Juliet N. ;

Scaradavou, Andromachi ;

Stevens, Cladd E. .

BLOOD, 2010, 115 (09) :1843-1849

[5] Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic disease [J].

Brunstein, Claudio G. ;

Barker, Juliet N. ;

Weisdorf, Daniel J. ;

DeFor, Todd E. ;

Miller, Jeffrey S. ;

Blazar, Bruce R. ;

McGlave, Philip B. ;

Wagner, John E. .

BLOOD, 2007, 110 (08) :3064-3070

[6] Allogeneic hematopoietic cell transplantation for hematologic malignancy: relative risks and benefits of double umbilical cord blood [J].

Brunstein, Claudio G. ;

Gutman, Jonathan A. ;

Weisdorf, Daniel J. ;

Woolfrey, Ann E. ;

DeFor, Todd E. ;

Gooley, Theodore A. ;

Verneris, Michael R. ;

Appelbaum, Frederick R. ;

Wagner, John E. ;

Delaney, Colleen .

BLOOD, 2010, 116 (22) :4693-4699

[7] Common and well-documented HLA alleles -: Report of the ad-hoc committee of the American Society for Histocompatiblity and Immunogenetics [J].

Cano, Pedro ;

Klitz, William ;

Mack, Steven J. ;

Maiers, Martin ;

Marsh, Steven G. E. ;

Noreen, Harriet ;

Reed, Elaine F. ;

Senitzer, David ;

Setterholm, Michelle ;

Smith, Anajane ;

Fernandez-Vina, Marcelo .

HUMAN IMMUNOLOGY, 2007, 68 (05) :392-417

[8] Reduced-Intensity Conditioning Stem Cell Transplantation: Comparison of Double Umbilical Cord Blood and Unrelated Donor Grafts [J].

Chen, Yi-Bin ;

Aldridge, Julie ;

Kim, Haesook T. ;

Ballen, Karen K. ;

Cutler, Corey ;

Kao, Grace ;

Liney, Deborah ;

Bourdeau, Greg ;

Alyea, Edwin P. ;

Armand, Philippe ;

Koreth, John ;

Ritz, Jerome ;

Spitzer, Thomas R. ;

Soiffer, Robert J. ;

Antin, Joseph H. ;

Ho, Vincent T. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2012, 18 (05) :805-812

[9] Impact of allele-level HLA matching on outcomes after myeloablative single unit umbilical cord blood transplantation for hematologic malignancy [J].

Eapen, Mary ;

Klein, John P. ;

Ruggeri, Annalisa ;

Spellman, Stephen ;

Lee, Stephanie J. ;

Anasetti, Claudio ;

Arcese, William ;

Barker, Juliet N. ;

Baxter-Lowe, Lee Ann ;

Brown, Maria ;

Fernandez-Vina, Marcelo A. ;

Freeman, John ;

He, Wensheng ;

Iori, Anna Paola ;

Horowitz, Mary M. ;

Locatelli, Franco ;

Marino, Susana ;

Maiers, Martin ;

Michel, Gerard ;

Sanz, Guillermo F. ;

Gluckman, Eliane ;

Rocha, Vanderson .

BLOOD, 2014, 123 (01) :133-140

[10] Effect of donor-recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis [J].

Eapen, Mary ;

Klein, John P. ;

Sanz, Guillermo F. ;

Spellman, Stephen ;

Ruggeri, Annalisa ;

Anasetti, Claudio ;

Brown, Maria ;

Champlin, Richard E. ;

Garcia-Lopez, Joan ;

Hattersely, Gareth ;

Koegler, Gesine ;

Laughlin, Mary J. ;

Michel, Gerard ;

Nabhan, Samir K. ;

Smith, Franklin O. ;

Horowitz, Mary M. ;

Gluckman, Eliane ;

Rocha, Vanderson .

LANCET ONCOLOGY, 2011, 12 (13) :1214-1221

← 1 2 3 →