From the laboratory to the clinic: How translational studies in animals have lead to clinical advances in boron neutron capture therapy

被引：6
|
作者：
Barth, Rolf F. [1 ]
机构：
[1] Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA
来源：
APPLIED RADIATION AND ISOTOPES | 2015年 / 106卷
基金：
美国国家卫生研究院;
关键词：
Sodium borocaptate (BSH); Boronophenylalanine (BPA); Melanomas and brain tumors; Optimization of delivery of BSH and BPA; DIAGNOSED GLIOBLASTOMA-MULTIFORME; BRAIN-BARRIER DISRUPTION; PARA-BORONOPHENYLALANINE; INTRACAROTID INJECTION; P-BORONOPHENYLALANINE; SODIUM BOROCAPTATE; ENHANCED SURVIVAL; TUMORS; DELIVERY;
D O I：
10.1016/j.apradiso.2015.06.016
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
In this report five examples have been selected to illustrate how studies in experimental animals have lead directly to clinical implementation. These include (1) the use of BSH as a boron delivery agent for BNCT of patients with brain tumors, and more specifically gliomas; (2) the use of BPA as a delivery agent for BNCT for patients with melanomas and (3) its subsequent use for BNCT of patients with gliomas; (4) optimization of the delivery of BPA in patients with gliomas; and finally (5) the combination of BSH and BPA with BNCT alone or together with X-irradiation to treat patients with gliomas. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：22 / 28
页数：7
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