From the laboratory to the clinic: How translational studies in animals have lead to clinical advances in boron neutron capture therapy

被引：6

作者：

Barth, Rolf F. ^{[1
]}

机构：

[1] Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA

来源：

APPLIED RADIATION AND ISOTOPES | 2015年 / 106卷

基金：

美国国家卫生研究院;

关键词：

Sodium borocaptate (BSH); Boronophenylalanine (BPA); Melanomas and brain tumors; Optimization of delivery of BSH and BPA; DIAGNOSED GLIOBLASTOMA-MULTIFORME; BRAIN-BARRIER DISRUPTION; PARA-BORONOPHENYLALANINE; INTRACAROTID INJECTION; P-BORONOPHENYLALANINE; SODIUM BOROCAPTATE; ENHANCED SURVIVAL; TUMORS; DELIVERY;

D O I：

10.1016/j.apradiso.2015.06.016

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

In this report five examples have been selected to illustrate how studies in experimental animals have lead directly to clinical implementation. These include (1) the use of BSH as a boron delivery agent for BNCT of patients with brain tumors, and more specifically gliomas; (2) the use of BPA as a delivery agent for BNCT for patients with melanomas and (3) its subsequent use for BNCT of patients with gliomas; (4) optimization of the delivery of BPA in patients with gliomas; and finally (5) the combination of BSH and BPA with BNCT alone or together with X-irradiation to treat patients with gliomas. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：22 / 28

页数：7

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