Melanocortin receptors in leptin effects

被引：444

作者：

Seeley, RJ

Yagaloff, KA

Fisher, SL

Burn, P

Thiele, TE

vanDijk, G

Baskin, DG

Schwartz, MW

机构：

[1] HOFFMANN LA ROCHE INC,DEPT METAB DIS,NUTLEY,NJ 07110

[2] UNIV WASHINGTON,HARBORVIEW MED CTR,DEPT PSYCHOL,SEATTLE,WA 98195

[3] UNIV WASHINGTON,HARBORVIEW MED CTR,DEPT MED,SEATTLE,WA 98195

[4] UNIV WASHINGTON,HARBORVIEW MED CTR,DEPT BIOL STRUCT,SEATTLE,WA 98195

[5] UNIV WASHINGTON,HARBORVIEW MED CTR,PUGET SOUND VA HLTH CARE SYST,SEATTLE,WA 98195

来源：

NATURE | 1997年 / 390卷 / 6658期

关键词：

D O I：

10.1038/37016

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Leptin acts on the central nervous system to cause a reduction in food intake and body weight1,2. The melanocortin system in the brain is also implicated in energy homeostasis, with agonists of the melanocortin-4 (MC4) receptor reducing food intake3 and targeted mutation of the MC4 receptor causing obesity4. We now show that MC4 receptor signalling is an important mediator of leptin's effects on food intake and body weight, demonstrating a link between the two systems.

引用

收藏

页码：349 / 349

页数：1

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