Nuclear Receptors in Hepatic Glucose and Lipid Metabolism During Neonatal and Adult Life

被引:9
作者
Cai, Demin [1 ,2 ]
Liu, Haoyu [3 ]
Zhao, Ruqian [1 ,4 ]
机构
[1] Nanjing Agr Univ, Coll Vet Med, Key Lab Anim Physiol & Biochem, Nanjing 210095, Jiangsu, Peoples R China
[2] Univ Calif Davis, Dept Biochem & Mol Med, Sacramento, CA 95817 USA
[3] Uppsala Univ, Dept Med Cell Biol, SE-75123 Uppsala, Sweden
[4] Jiangsu Collaborat Innovat Ctr Meat Prod & Proc Q, Nanjing 210095, Jiangsu, Peoples R China
关键词
Nuclear receptors; fetal programming; liver; glucose; lipid; metabolism; REV-ERB-ALPHA; FARNESOID-X-RECEPTOR; PROLIFERATOR-ACTIVATED RECEPTORS; GLUCONEOGENIC GENE-EXPRESSION; LIVER-X; GLUCOCORTICOID-RECEPTOR; FATTY-ACID; PHOSPHOENOLPYRUVATE CARBOXYKINASE; ROR-ALPHA; DNA-BINDING;
D O I
10.2174/1389203717666160627081751
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Research efforts focusing on metabolic diseases have established a close conjunction between glucolipid abnormalities and nuclear receptors, a large superfamily of receptors including classic peroxisome proliferation-activated receptors (PPARs), liver X receptors (LXRs), farnesoid X receptors (FXRs) and glucocorticoid receptors (GRs) together with burgeoning retinoic acid receptor-related orphan receptors (RORs) and REV-ERBs. Nuclear receptors are identified to control a series of physiological and pathological processes of glucose and lipid metabolism and also implicated to mediate the long-term effects of early environmental and nutritional experiences on the formation of adult chronic metabolic disorders in human and animals. Thus, nuclear receptors play profound roles in fetal programming and adult regulation of glucolipid metabolism. In this review, we provide an overview on the recent advances in the field of nuclear receptors focusing on their roles in lipid and glucose metabolism during early and late life courses. We hope that this knowledge may shed new lights on identifying the novel target molecules or pathways for the prevention and treatment of metabolic disorders involving disrupted glucose and lipid homeostasis in human and animals.
引用
收藏
页码:548 / 561
页数:14
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