ERα in the Control of Mitochondrial Function and Metabolic Health

被引：21

作者：

Hevener, Andrea L. ^{[1
,2
]}

Ribas, Vicent ^{[1
,3
]}

Moore, Timothy M. ^{[1
]}

Zhou, Zhenqi ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Endocrinol Diabet & Hypertens, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Iris Cantor UCLA Womens Hlth Res Ctr, Los Angeles, CA 90095 USA

[3] Spanish Natl Res Council, Dept Cell Death & Proliferat, Inst Invest Biomed Barcelona, IIBB CSIC, C Rossello 179, Barcelona 08036, Spain

来源：

TRENDS IN MOLECULAR MEDICINE | 2021年 / 27卷 / 01期

基金：

美国国家卫生研究院;

关键词：

ESTROGEN-RECEPTOR-ALPHA; ACTIVATED PROTEIN-KINASE; INDUCED INSULIN-RESISTANCE; HIGH-FAT-DIET; SKELETAL-MUSCLE; HORMONE-THERAPY; OXIDATIVE-METABOLISM; STEROID-RECEPTORS; ADIPOSE-TISSUE; RISK-FACTOR;

D O I：

10.1016/j.molmed.2020.09.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Decrements in metabolic health elevate disease risk, including type 2 diabetes, heart disease, and certain cancers. Thus, treatment strategies to combat metabolic dysfunction are needed. Reduced ESR1 (estrogen receptor, ER alpha) expression is observed in muscle from women, men, and animals presenting clinical features of the metabolic syndrome. Human studies of natural expression of ESR1 in metabolic tissues show that muscle expression of ESR1 is positively correlated with markers of metabolic health, including insulin sensitivity. Herein, we highlight the important impact of ER alpha on mitochondrial form and function and present how these actions of the receptor govern metabolic homeostasis. Studies identifying ER alpha-regulated pathways for disease prevention will lay the foundation for the design of novel therapeutics to improve the health of women while limiting secondary complications that have plagued traditional hormone replacement interventions.

引用

页码：31 / 46

页数：16

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