TREATMENT OF A PEDIATRIC PATIENT WITH AN H3.3 K27M MUTANT DIPG WITH ONC201, A SELECTIVE DRD2 ANTAGONIST

被引：0
|
作者：
Suarez, Fernando [1 ]
Stafford, James M. [1 ]
Tarapore, Rohinton [2 ]
Oster, Wolfgang [2 ]
Allen, Joshua E. [2 ]
Chi, Andrew S. [1 ]
Gardner, Sharon [1 ]
机构：
[1] NYU Langone Hlth, New York, NY USA
[2] Oncoceutics, Philadelphia, PA USA
来源：
NEURO-ONCOLOGY | 2018年 / 20卷
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
DIPG-54
引用
收藏
页码：60 / 60
页数：1
相关论文
共 50 条
  • [1] Pediatric and adult H3 K27M-mutant diffuse midline glioma treated with the selective DRD2 antagonist ONC201
    Andrew S. Chi
    Rohinton S. Tarapore
    Matthew D. Hall
    Nicole Shonka
    Sharon Gardner
    Yoshie Umemura
    Ashley Sumrall
    Ziad Khatib
    Sabine Mueller
    Cassie Kline
    Wafik Zaky
    Soumen Khatua
    Shiao-Pei Weathers
    Yazmin Odia
    Toba N. Niazi
    Doured Daghistani
    Irene Cherrick
    David Korones
    Matthias A. Karajannis
    Xiao-Tang Kong
    Jane Minturn
    Angela Waanders
    Isabel Arillaga-Romany
    Tracy Batchelor
    Patrick Y. Wen
    Krystal Merdinger
    Lee Schalop
    Martin Stogniew
    Joshua E. Allen
    Wolfgang Oster
    Minesh P. Mehta
    Journal of Neuro-Oncology, 2019, 145 : 97 - 105
  • [2] Pediatric and adult H3 K27M-mutant diffuse midline glioma treated with the selective DRD2 antagonist ONC201
    Chi, Andrew S.
    Tarapore, Rohinton S.
    Hall, Matthew D.
    Shonka, Nicole
    Gardner, Sharon
    Umemura, Yoshie
    Sumrall, Ashley
    Khatib, Ziad
    Mueller, Sabine
    Kline, Cassie
    Zaky, Wafik
    Khatua, Soumen
    Weathers, Shiao-Pei
    Odia, Yazmin
    Niazi, Toba N.
    Daghistani, Doured
    Cherrick, Irene
    Korones, David
    Karajannis, Matthias A.
    Kong, Xiao-Tang
    Minturn, Jane
    Waanders, Angela
    Arillaga-Romany, Isabel
    Batchelor, Tracy
    Wen, Patrick Y.
    Merdinger, Krystal
    Schalop, Lee
    Stogniew, Martin
    Allen, Joshua E.
    Oster, Wolfgang
    Mehta, Minesh P.
    JOURNAL OF NEURO-ONCOLOGY, 2019, 145 (01) : 97 - 105
  • [3] Selective DRD2 antagonist and ClpP agonist ONC201 in a recurrent non-midline H3 K27M-mutant glioma cohort
    Odia, Yazmin
    Hall, Matthew D.
    Cloughesy, Timothy Francis
    Wen, Patrick Y.
    Arrillaga-Romany, Isabel
    Daghistani, Doured
    Mehta, Minesh P.
    Tarapore, Rohinton S.
    Ramage, Samuel C.
    Allen, Joshua E.
    NEURO-ONCOLOGY, 2024, 26 : S165 - S172
  • [4] First clinical experience with DRD2/3 antagonist ONC201 in H3 K27M-mutant pediatric diffuse intrinsic pontine glioma: a case report
    Hall, Matthew D.
    Odia, Yazmin
    Allen, Joshua E.
    Tarapore, Rohinton
    Khatib, Ziad
    Niazi, Toba N.
    Daghistani, Doured
    Schalop, Lee
    Chi, Andrew S.
    Oster, Wolfgang
    Mehta, Minesh P.
    JOURNAL OF NEUROSURGERY-PEDIATRICS, 2019, 23 (06) : 719 - 725
  • [5] ONCOGENIC MECHANISMS OF H3.3 K27M IN A SPONTANEOUS DIPG MOUSE MODEL
    Larson, Jon
    Kasper, Lawryn
    Paugh, Barbara
    Wu, Gang
    Jin, Hongjian
    Fan, Yiping
    Kwon, Chang-Hyuk
    Finkelstein, David
    Silveira, Andre
    Xu, Raymond
    Zhu, Xiaoyan
    Zhang, Junyuan
    Xu, Beisi
    Russell, Helen
    McKinnon, Peter
    Ellison, David
    Zhang, Jinghui
    Baker, Suzanne
    NEURO-ONCOLOGY, 2018, 20 : 63 - 63
  • [6] Oncogenic activity of H3.3 K27M in a spontaneous DIPG mouse model
    Larson, Jon D.
    Kasper, Lawryn H.
    Wu, Gang
    Fan, Yiping
    Finkelstein, David
    Jin, Hongjian
    Paugh, Barbara S.
    Silveira, Andre B.
    Xu, Beisi
    Zhu, Xiaoyan
    Zhang, Junyuan
    Russell, Helen R.
    McKinnon, Peter J.
    Ellison, David W.
    Zhang, Jinghui
    Baker, Suzanne J.
    CANCER RESEARCH, 2017, 77
  • [7] ONC201 in previously irradiated pediatric H3 K27M-mutant glioma or newly diagnosed DIPG.
    Gardner, Sharon L.
    Koschmann, Carl Johannes
    Tarapore, Rohinton
    Allen, Jeffrey C.
    Zaky, Wafik Tharwat
    Odia, Yazmin
    Hall, Matthew
    Daghistani, Doured
    Khatib, Ziad
    Aguilera, Dolly
    MacDonald, Tobey J.
    Fouladi, Maryam
    McGovern, Susan Lynne
    Kline, Cassie
    Vitanza, Nicholas A.
    Lu, Guangrong
    Oster, Wolfgang
    Allen, Joshua E.
    Khatua, Soumen
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
  • [8] INCREASE HISTONE METHYLATION FOR THE TREATMENT OF H3.3 K27M MUTANT BRAINSTEM GLIOMAS
    Hashizume, Rintaro
    Ihara, Yuichiro
    Andor, Noemi
    Chen, Xiaoyue
    Lerner, Robin
    Huang, Xi
    Tom, Maxwell
    Solomon, David
    Mueller, Sabine
    Petritsch, Claudia
    Zhang, Zhiguo
    Gupta, Nalin
    Waldman, Todd
    James, David
    NEURO-ONCOLOGY, 2014, 16 : 54 - 54
  • [9] In vitro Efficacy of the Dopamine Receptor D2 (DRD2) Antagonist ONC201, for the Treatment of Diffuse Intrinsic Pontine Glioma (DIPG)
    Jackson, Evangeline R.
    Duchatel, Ryan J.
    Dun, Andmatthew D.
    ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 2019, 15 : 31 - 31
  • [10] Clinical activity of the selective DRD2 antagonist ONC201, an imipridone, in metastatic endometrial cancer (mEC).
    Rodriguez-Rodriguez, Lorna
    Mehnert, Janice M.
    Silk, Ann W.
    Chan, Nancy
    Malhotra, Jyoti
    Aisner, Joseph
    Saunders, Tracie
    Yu, Bangning
    Dickerson, Siobhan
    Tarapore, Rohinton
    Allen, Joshua E.
    Stogniew, Martin
    Oster, Wolfgang
    Kaufman, Howard
    Haffty, Bruce George
    Bertino, Joseph R.
    Stein, Mark N.
    JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
12345