The attributable risk of chronic obstructive pulmonary disease due to ambient fine particulate pollution among older adults

被引:58
作者
Lin, Hualiang [1 ]
Qian, Zhengmin [2 ]
Guo, Yanfei [3 ]
Zheng, Yang [3 ]
Ai, Siqi [1 ]
Hang, Jian [4 ]
Wang, Xiaojie [5 ]
Zhang, Lingli [5 ]
Liu, Tao [5 ]
Guan, Weijie [6 ]
Li, Xing [5 ]
Xiao, Jianpeng [5 ]
Zeng, Weilin [5 ]
Xian, Hong [2 ]
Howard, Steven W. [2 ]
Ma, Wenjun [5 ]
Wu, Fan [3 ]
机构
[1] Sun Yat Sen Univ, Sch Publ Hlth, Dept Med Stat & Epidemiol, Guangzhou, Guangdong, Peoples R China
[2] St Louis Univ, Coll Publ Hlth & Social Justice, St Louis, MO 63103 USA
[3] Shanghai Municipal Ctr Dis Control & Prevent, Shanghai, Peoples R China
[4] Sun Yat Sen Univ, Sch Atmospher Sci, Guangzhou, Guangdong, Peoples R China
[5] Guangdong Prov Ctr Dis Control & Prevent, Guangdong Prov Inst Publ Hlth, Guangzhou 511430, Guangdong, Peoples R China
[6] Guangzhou Med Univ, Affiliated Hosp 1, Natl Clin Res Ctr Resp Dis, State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China
关键词
Air pollution; COPD; Disease burden; Effect modification; LONG-TERM EXPOSURE; AIR-POLLUTION; DIESEL EXHAUST; GLOBAL BURDEN; MORTALITY; MATTER; COPD; ASSOCIATION; HOSPITALIZATION; PREVALENCE;
D O I
10.1016/j.envint.2018.01.029
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Background: The linkage between ambient fine particle pollution (PM2.5) and chronic obstructive pulmonary disease (COPD) and the attributable risk remained largely unknown. This study determined the cross-sectional association between ambient PM2.5 and prevalence of COPD among adults >= 50 years of age. Methods: We surveyed 29,290 participants aged 50 years and above in this study. The annual average concentrations of PM2.5 derived from satellite data were used as the exposure indicator. A mixed effect model was applied to determine the associations and the burden of COPD attributable to PM2.5. Results: Among the participants, 1872 (6.39%) were classified as COPD cases. Our analysis observed a threshold concentration of 30 mu g/m(3) in the PM2.5-COPD association, above which we found a linear positive exposure-response association between ambient PM2.5 and COPD. The odds ratio (OR) for each 10 mu g/m(3) increase in ambient PM2.5 was 1.21(95% CI: 1.13, 1.30). Stratified analyses suggested that males, older subjects (65 years and older) and those with lower education attainment might be the vulnerable subpopulations. We further estimated that about 13.79% (95% CI: 7.82%, 21.62%) of the COPD cases could be attributable to PM2.5 levels higher than 30 mu g/m(3) in the study population. Conclusion: Our analysis indicates that ambient PM2.5 exposure could increase the risk of COPD and accounts for a substantial fraction of COPD among the study population.
引用
收藏
页码:143 / 148
页数:6
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