P(i-PrNCH2CH2)3N: an efficient catalyst for TMS-1,3-dithiane addition to aldehydes

被引：7
作者：
Wadhwa, Kuldeep [1 ]
Verkade, John G. [1 ]
机构：
[1] Iowa State Univ, Dept Chem, Ames, IA 50011 USA
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 30期
基金：
美国国家科学基金会;
关键词：
CARBONYL-COMPOUNDS; PROAZAPHOSPHATRANES; P(I-BUNCH2CH2)(3)N; DESILYLATION; SILYLATION; CARBANIONS; PROMOTER; KETONES;
D O I：
10.1016/j.tetlet.2009.05.010
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein we report the use of commercially available P(i-PrNCH2CH2)(3)N (1a) as an efficient catalyst for 2-trimethylsilyl-1,3-dithiane (TMS-dithiane) addition to aldehydes at room temperature. The catalyst loading required for these reactions (5 mol %) is the lowest recorded in the literature, and the majority of the reaction times for this transformation are the shortest thus far reported. A variety of functional groups are tolerated on the aryl aldehyde substrates. (C) 2009 Elsevier Ltd. All rights reserved.
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页码：4307 / 4309
页数：3
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