Intestinal stem cell transplantation

被引：8

作者：

Nakamura, Tetsuya ^{[1
]}

Watanabe, Mamoru ^{[2
]}

机构：

[1] Tokyo Med & Dent Univ, Dept Adv Therapeut GI Dis, Tokyo 1138519, Japan

[2] Tokyo Med & Dent Univ, Dept Gastroenterol & Hepatol, Tokyo 1138519, Japan

来源：

JOURNAL OF GASTROENTEROLOGY | 2017年 / 52卷 / 02期

关键词：

Intestinal stem cell; Organoid technology; Transplantation; Regenerative medicine; IN-VITRO EXPANSION; MODELING DEVELOPMENT; ORGANOIDS; DIFFERENTIATION; EPITHELIUM; DISEASE; COLON; CRYPT; NICHE; HOMEOSTASIS;

D O I：

10.1007/s00535-016-1288-8

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Organoid technologies to expand intestinal epithelial cells are gaining increasing attention as a useful tool to investigate many aspects of intestinal epithelial biology and pathology. One important application of organoid systems would be to use intestinal epithelial cells expanded in culture for following transplantation experiments. In this article, we present a brief overview of the studies that have succeeded in generating new epithelial tissues in the surface of native intestines in mice by organoid transplantation. We also discuss possible applications of this experimental approach in basic research on the intestinal epithelium as well as in regenerative medicine for various types of intestinal diseases in humans.

引用

页码：151 / 157

页数：7

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