Intestinal stem cell transplantation

被引：8
|
作者：
Nakamura, Tetsuya [1 ]
Watanabe, Mamoru [2 ]
机构：
[1] Tokyo Med & Dent Univ, Dept Adv Therapeut GI Dis, Tokyo 1138519, Japan
[2] Tokyo Med & Dent Univ, Dept Gastroenterol & Hepatol, Tokyo 1138519, Japan
来源：
JOURNAL OF GASTROENTEROLOGY | 2017年 / 52卷 / 02期
关键词：
Intestinal stem cell; Organoid technology; Transplantation; Regenerative medicine; IN-VITRO EXPANSION; MODELING DEVELOPMENT; ORGANOIDS; DIFFERENTIATION; EPITHELIUM; DISEASE; COLON; CRYPT; NICHE; HOMEOSTASIS;
D O I：
10.1007/s00535-016-1288-8
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Organoid technologies to expand intestinal epithelial cells are gaining increasing attention as a useful tool to investigate many aspects of intestinal epithelial biology and pathology. One important application of organoid systems would be to use intestinal epithelial cells expanded in culture for following transplantation experiments. In this article, we present a brief overview of the studies that have succeeded in generating new epithelial tissues in the surface of native intestines in mice by organoid transplantation. We also discuss possible applications of this experimental approach in basic research on the intestinal epithelium as well as in regenerative medicine for various types of intestinal diseases in humans.
引用
收藏
页码：151 / 157
页数：7
相关论文
共 50 条
  • [21] Regulation of intestinal stem cell activity by a mitotic cell cycle regulator Polo in Drosophila
    Zhang, Ying
    Chen, Rongbing
    Gong, Liyuan
    Huang, Wuren
    Li, Ping
    Zhai, Zongzhao
    Ling, Erjun
    G3-GENES GENOMES GENETICS, 2023, 13 (06):
  • [22] Intestinal stem cells and intestinal organoids
    Zhao, Qian
    Guan, Jiawei
    Wang, Xia
    JOURNAL OF GENETICS AND GENOMICS, 2020, 47 (06) : 289 - 299
  • [23] Location, location, location! The reality of life for an intestinal stem cell in the crypt
    Walther, Viola
    Graham, Trevor A.
    JOURNAL OF PATHOLOGY, 2014, 234 (01) : 1 - 4
  • [24] Tracing oncogene-driven remodelling of the intestinal stem cell niche
    Yum, Min Kyu
    Han, Seungmin
    Fink, Juergen
    Wu, Szu-Hsien Sam
    Dabrowska, Catherine
    Trendafilova, Teodora
    Mustata, Roxana
    Chatzeli, Lemonia
    Azzarelli, Roberta
    Pshenichnaya, Irina
    Lee, Eunmin
    England, Frances
    Kim, Jong Kyoung
    Stange, Daniel E.
    Philpott, Anna
    Lee, Joo-Hyeon
    Koo, Bon-Kyoung
    Simons, Benjamin D.
    NATURE, 2021, 594 (7863) : 442 - +
  • [25] Stem cell transplantation in multiple sclerosis
    Uccelli, Antonio
    Mancardi, Gianluigi
    CURRENT OPINION IN NEUROLOGY, 2010, 23 (03) : 218 - 225
  • [26] Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications
    Sato, Toshiro
    Clevers, Hans
    SCIENCE, 2013, 340 (6137) : 1190 - 1194
  • [27] Ophthalmologic stem cell transplantation therapies
    Blenkinsop, Timothy A.
    Corneo, Barbara
    Temple, Sally
    Stern, Jeffrey H.
    REGENERATIVE MEDICINE, 2012, 7 (06) : 32 - 39
  • [28] Hematopoietic stem cell transplantation in SCD
    Dalle, Jean-Hugues
    COMPTES RENDUS BIOLOGIES, 2013, 336 (03) : 148 - 151
  • [29] Concise Review: The Potential Use of Intestinal Stem Cells to Treat Patients with Intestinal Failure
    Hong, Sung Noh
    Dunn, James C. Y.
    Stelzner, Matthias
    Martin, Martin G.
    STEM CELLS TRANSLATIONAL MEDICINE, 2017, 6 (02) : 666 - 676
  • [30] Arid1a is essential for intestinal stem cells through Sox9 regulation
    Hiramatsu, Yukiko
    Fukuda, Akihisa
    Ogawa, Satoshi
    Goto, Norihiro
    Ikuta, Kozo
    Tsuda, Motoyuki
    Matsumoto, Yoshihide
    Kimura, Yoshito
    Yoshioka, Takuto
    Takada, Yutaka
    Maruno, Takahisa
    Hanyu, Yuta
    Tsuruyama, Tatsuaki
    Wang, Zhong
    Akiyama, Haruhiko
    Takaishi, Shigeo
    Miyoshi, Hiroyuki
    Taketo, Makoto Mark
    Chiba, Tsutomu
    Seno, Hiroshi
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (05) : 1704 - 1713
12345