REGIOSELECTIVE SYNTHESIS OF PYRAZOLES AND PYRAZOLO[1,5-α] PYRIMIDINES: STRUCTURAL CHARACTERIZATION BY HMBC NMR

被引：4

作者：

Al-Bogami, Abdullah S. ^{[1
]}

Saleh, Tamer S. ^{[1
,2
]}

机构：

[1] King Abdulaziz Univ, Dept Chem, Fac Sci, Jeddah 21589, Saudi Arabia

[2] Natl Res Ctr, Green Chem Dept, Cairo 12622, Egypt

来源：

HETEROCYCLES | 2015年 / 91卷 / 09期

关键词：

Coumarin; 2D HMBC NMR; Microwave Irradiation; Pyrazole; Pyrazolo[1,5-a]pyrimidine; SILYLATED BETA-ENAMINONES; SINGLE-STEP SYNTHESIS; ANTIMICROBIAL EVALUATION; HETEROCYCLIC SYNTHESIS; DERIVATIVES; MOIETY; AGGRESSION; ANTICANCER; INHIBITORS; HYDRAZINES;

D O I：

10.3987/COM-15-13267

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this study a series of novel pyrazoles and pyrazolo [1,5-alpha]pyrimidines with a sulfone moiety incorporated the coumarin ring were efficiently synthesized. These pyrazoles and pyrazolo[1,5-alpha]pyrimidines were synthesized by treating enaminone derivative of beta-ketosulfone (3-(2-tosylacety1)-2H-coumarin) with substituted hydrazines and 5-aminopyrazole derivatives, respectively under microwave irradiation. The structures of the products thus obtained were characterized by 2D NMR (HMBC).

引用

页码：1781 / 1796

页数：16

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